INSERM U932, 26 Rue d'Ulm, 75005 Paris, France.
Nat Rev Immunol. 2012 Jul 13;12(8):557-69. doi: 10.1038/nri3254.
The presentation of exogenous antigens on MHC class I molecules, known as cross-presentation, is essential for the initiation of CD8(+) T cell responses. In vivo, cross-presentation is mainly carried out by specific dendritic cell (DC) subsets through an adaptation of their endocytic and phagocytic pathways. Here, we summarize recent advances in our understanding of the intracellular mechanisms of cross-presentation and discuss its role in immunity and tolerance in the context of specialization between DC subsets. Finally, we review current strategies to use cross-presentation for immunotherapy.
外源性抗原在 MHC Ⅰ类分子上的呈递，称为交叉呈递，是启动 CD8(+) T 细胞应答的关键。在体内，交叉呈递主要通过特定树突状细胞（DC）亚群对其内吞和吞噬途径的适应性来完成。在这里，我们总结了我们对交叉呈递的细胞内机制的理解的最新进展，并讨论了它在 DC 亚群之间的专业化背景下在免疫和耐受中的作用。最后，我们回顾了利用交叉呈递进行免疫治疗的当前策略。
