Schoeller D A, Dietz W, van Santen E, Klein P D
Am J Clin Nutr. 1982 Mar;35(3):591-4. doi: 10.1093/ajcn/35.3.591.
The use of saliva sampling for the measurement of total body water by H2 18O stable isotope dilution was assessed. The H2 18O abundance in saliva reached a constant value by three hours after isotope administration, and the total body water calculated from the 3-h saliva values was not significantly different from the value calculated from the 4- and 6-h serum samples. The results indicated that isotopic equilibration between these fluids was rapid and complete. Comparison of total body water calculated from the paired serum and saliva studies indicated that the relative precision of the determination was between 0.8 and 1.5%. Saliva sampling is noninvasive and is well suited for use in children in field studies.
评估了通过H2 18O稳定同位素稀释法利用唾液采样测量全身水含量的情况。同位素给药后三小时，唾液中的H2 18O丰度达到恒定值，根据3小时唾液值计算出的全身水含量与根据4小时和6小时血清样本计算出的值无显著差异。结果表明，这些体液之间的同位素平衡迅速且完全。对配对血清和唾液研究计算出的全身水含量进行比较表明，测定的相对精密度在0.8%至1.5%之间。唾液采样是非侵入性的，非常适合用于野外研究中的儿童。
