Kozlov Iu A, Loktiushina T A
Biull Eksp Biol Med. 1990 Oct;110(10):404-6.
Alloxan diabetes (sucrose blood concentrate greater than or equal to 14 mmol/l decreased the life time of blood lymphocytes and increased the migration of these cells from lymphatic organs in BALB/c male mice. The proliferation pools of lymphoblasts and prolymphocytes in the thymus of diabetic mice were depressed, but in the lymphatic nodes remained unchanged. It has been shown that in lymphoid cells of the thymus of mice with diabetes the generation time and the time of G1- and G2-phase were significantly increased, but the time of the S-phase of the life cycle of these cells was normal. Proliferation of the lymphoid cells in lymphatic nodes was insulin-dependent. It has been shown that in the prolymphocytes of lymphatic nodes from diabetic mice the duration of the G1-phase was significantly decreased.
四氧嘧啶糖尿病（血糖中蔗糖浓度大于或等于14毫摩尔/升）缩短了BALB/c雄性小鼠血液淋巴细胞的寿命，并增加了这些细胞从淋巴器官的迁移。糖尿病小鼠胸腺中淋巴母细胞和前淋巴细胞的增殖池受到抑制，但在淋巴结中保持不变。研究表明，糖尿病小鼠胸腺的淋巴细胞中，细胞周期的生成时间以及G1期和G2期的时间显著增加，但这些细胞生命周期的S期时间正常。淋巴结中淋巴细胞的增殖是胰岛素依赖性的。研究表明，糖尿病小鼠淋巴结的前淋巴细胞中，G1期的持续时间显著缩短。
