de Sousa M
Clin Exp Immunol. 1971 Sep;9(3):371-80.
The differences between the fate of mouse thymus and marrow cells labelled with [H]adenosine following intravenous injection into syngeneic recipients are defined. Thymus cells home predominantly to the thymus–dependent territory in the recipient's peripheral lymphoid organs, whereas the majority of bone marrow cells is found in thymus–independent sites. In addition, it is shown that a marrow inoculum contains a variety of sub-populations able to discriminate microenvironmental differences within the thymus–independent territory itself. In general, cell populations behave as if they have the ability to distinguish and home towards what is probably their usual environment. The word `ecotaxis' is offered to define this phenomenon, and the mechanisms that may be involved in determining it are discussed.
已明确静脉注射到同基因受体体内的经[H]腺苷标记的小鼠胸腺细胞和骨髓细胞在命运上的差异。胸腺细胞主要归巢到受体外周淋巴器官中依赖胸腺的区域，而大多数骨髓细胞则存在于不依赖胸腺的部位。此外，研究表明骨髓接种物包含多种亚群，这些亚群能够区分不依赖胸腺区域内的微环境差异。一般来说，细胞群体的行为就好像它们有能力区分并归巢到可能是它们通常所处的环境。提出“生态趋化”一词来定义这一现象，并讨论了可能参与确定这一现象的机制。
