Kozlov Iu A, Timofeeva E E, Zinger M G
Biull Eksp Biol Med. 1986 Apr;101(4):407-9.
Alloxan diabetes (sucrose blood concentration greater than or equal to 14 mmol/l) induced lymphocytopenia in noninbred male mice, resulting from the decrease in the number of both T and B lymphocytes differentiated by their reaction to acid phosphatase. At the same time thymic bone marrow lymphopoiesis in mice with diabetes was depressed. Nodular and splenic lymphopoiesis remained virtually unchanged. These disturbances became apparent on the 3rd week after diabetes induction. Alloxan itself has no inhibitory effect on lymphopoiesis.
四氧嘧啶糖尿病（血糖浓度大于或等于14毫摩尔/升）可导致非近交系雄性小鼠淋巴细胞减少，这是由于T淋巴细胞和B淋巴细胞数量减少所致，这些细胞是通过它们对酸性磷酸酶的反应而分化的。与此同时，糖尿病小鼠的胸腺骨髓淋巴细胞生成受到抑制。结节性和脾脏淋巴细胞生成基本保持不变。这些紊乱在糖尿病诱导后的第3周变得明显。四氧嘧啶本身对淋巴细胞生成没有抑制作用。
