单次给予2-氯乙基亚硝脲治愈大鼠急性白血病L 5222后发生的第二原发性恶性肿瘤
Development of second malignancies in rats after cure of acute leukemia L 5222 by single doses of 2-chloroethylnitrosoureas.
作者信息
Zeller W J, Schmähl D
出版信息
J Cancer Res Clin Oncol. 1979 Sep;95(1):83-6. doi: 10.1007/BF00411113.
Abstract
After cure of rat leukemia L 5222 in 79 BD IX rats by single doses of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea (Hydroxyethyl-CNU) a total of 9 rats (11%) developed secondary malignomas.
摘要
用单剂量的1,3-双(2-氯乙基)-1-亚硝基脲(卡氮芥)或1-(2-羟乙基)-3-(2-氯乙基)-3-亚硝基脲(羟乙基亚硝脲)治愈79只BD IX大鼠的白血病L 5222后，共有9只大鼠(11%)发生了继发性恶性肿瘤。
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