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新型合成的2-氯乙基亚硝基脲对大鼠白血病L 5222的研究。

Examination of newly synthesized 2-chloroethyl-nitrosoureas on rat leukemia L 5222.

作者信息

Zeller W J, Eisenbrand G

出版信息

Oncology. 1981;38(1):39-42. doi: 10.1159/000225519.

DOI:10.1159/000225519
PMID:7443175
Abstract

The preterminal intraperitoneal implanted rat leukemia L 5222 was used to test the chemotherapeutic activity of 10 newly synthesized nitrosoureas: ethylmethanesulfonato-CNU, acetamido-CNU, dihydroxypropyl-CNU, carboxyethyl-CNU, cyanoethyl-CNU, morpholino-CNU, piperidino-CNU, methylene-dioxybenzyl-CNU, methylene-3-pyridyl-CNU and methylene-4-pyridyl-CNU; their activity was compared against BCNU, CCNU, MeCCNU and hydroxyethyl-CNU. All compounds tested showed a more or less pronounced chemotherapeutic activity. MeCCNU was superior to all other compounds investigated. The predictive value for human tumors of results obtained from a model which is highly sensitive to nitrosoureas is discussed.

摘要

采用终末期腹腔内植入大鼠白血病L 5222模型来测试10种新合成的亚硝基脲类药物的化疗活性：甲磺酸乙酯-CCNU、乙酰氨基-CCNU、二羟丙基-CCNU、羧乙基-CCNU、氰乙基-CCNU、吗啉代-CCNU、哌啶代-CCNU、亚甲二氧基苄基-CCNU、亚甲基-3-吡啶基-CCNU和亚甲基-4-吡啶基-CCNU；将它们的活性与卡氮芥、洛莫司汀、司莫司汀和羟乙基-CCNU进行比较。所有测试化合物均表现出或多或少明显的化疗活性。司莫司汀优于所有其他研究的化合物。讨论了从对亚硝基脲类高度敏感的模型获得的结果对人类肿瘤的预测价值。

相似文献

1
Examination of newly synthesized 2-chloroethyl-nitrosoureas on rat leukemia L 5222.新型合成的2-氯乙基亚硝基脲对大鼠白血病L 5222的研究。
Oncology. 1981;38(1):39-42. doi: 10.1159/000225519.
2
Examination of four newly synthesized 2-chloroethylnitrosoureas in comparison with BCNU, CCNU, MeCCNU, chlorozotocin and hydroxyethyl-CNU in preterminal rat leukemia L 5222.将四种新合成的2-氯乙基亚硝脲与卡莫司汀、洛莫司汀、司莫司汀、链脲佐菌素和羟乙基亚硝脲在晚期大鼠白血病L 5222中进行比较研究。
J Cancer Res Clin Oncol. 1979 Sep;95(1):43-9. doi: 10.1007/BF00411108.
3
Examination of newly synthesized 2-chloroethylnitrosoureas in preterminal leukemia L 5222 and in two transplanted neurogenic tumors.
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Chemotherapeutic activity of new 2-chloroethylnitrosoureas in rat L5222 leukemia: comparison of bifunctional and water-soluble derivatives with 1,3-bis(2-chloroethyl)-1-nitrosourea.
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Drug design: nitrosoureas.药物设计：亚硝基脲类
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Some new congeners of the anticancer agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Synthesis of bifunctional analogs and water soluble derivatives and preliminary evaluation of their chemotherapeutic potential.抗癌剂1,3-双（2-氯乙基）-1-亚硝基脲（卡莫司汀）的一些新同系物。双功能类似物和水溶性衍生物的合成及其化疗潜力的初步评估。
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Reaction of N-(2-chloroethyl)-N-nitrosoureas with DNA: effect of buffers on DNA adduction, cross-linking, and cytotoxicity.N-（2-氯乙基）-N-亚硝基脲与DNA的反应：缓冲液对DNA加合、交联及细胞毒性的影响
Chem Res Toxicol. 1996 Jan-Feb;9(1):208-14. doi: 10.1021/tx950097g.

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Evaluation of new estrogen-linked 2-chloroethylnitrosoureas. I. Short term anticancer efficacy in methylnitrosourea-induced rat mammary carcinoma and hormonal activity in mice.新型雌激素连接的2-氯乙基亚硝脲的评估。I. 对甲基亚硝脲诱导的大鼠乳腺癌的短期抗癌疗效及对小鼠的激素活性
J Cancer Res Clin Oncol. 1984;108(1):148-53. doi: 10.1007/BF00390987.
3
Antineoplastic activity of esters and amides of N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-aminoacids.
N-[N'-(2-氯乙基)-N'-亚硝基氨基甲酰基]-氨基酸酯和酰胺的抗肿瘤活性
J Cancer Res Clin Oncol. 1984;108(2):249-51. doi: 10.1007/BF00402478.
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L1210 leukemia i.v. implanted as a model for testing short-chain nitrosourea analogs.将L1210白血病通过静脉注射植入作为测试短链亚硝基脲类似物的模型。
J Cancer Res Clin Oncol. 1986;111(1):31-4. doi: 10.1007/BF00402772.
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Anti-tumour, toxicological and pharmacokinetic properties of a novel taurine-based nitrosourea (TCNU).一种新型牛磺酸基亚硝基脲（TCNU）的抗肿瘤、毒理学及药代动力学特性
Invest New Drugs. 1988 Apr;6(1):19-30. doi: 10.1007/BF00170775.