新型合成的2-氯乙基亚硝基脲对大鼠白血病L 5222的研究。
Examination of newly synthesized 2-chloroethyl-nitrosoureas on rat leukemia L 5222.
作者信息
Zeller W J, Eisenbrand G
出版信息
Oncology. 1981;38(1):39-42. doi: 10.1159/000225519.
The preterminal intraperitoneal implanted rat leukemia L 5222 was used to test the chemotherapeutic activity of 10 newly synthesized nitrosoureas: ethylmethanesulfonato-CNU, acetamido-CNU, dihydroxypropyl-CNU, carboxyethyl-CNU, cyanoethyl-CNU, morpholino-CNU, piperidino-CNU, methylene-dioxybenzyl-CNU, methylene-3-pyridyl-CNU and methylene-4-pyridyl-CNU; their activity was compared against BCNU, CCNU, MeCCNU and hydroxyethyl-CNU. All compounds tested showed a more or less pronounced chemotherapeutic activity. MeCCNU was superior to all other compounds investigated. The predictive value for human tumors of results obtained from a model which is highly sensitive to nitrosoureas is discussed.
采用终末期腹腔内植入大鼠白血病L 5222模型来测试10种新合成的亚硝基脲类药物的化疗活性：甲磺酸乙酯-CCNU、乙酰氨基-CCNU、二羟丙基-CCNU、羧乙基-CCNU、氰乙基-CCNU、吗啉代-CCNU、哌啶代-CCNU、亚甲二氧基苄基-CCNU、亚甲基-3-吡啶基-CCNU和亚甲基-4-吡啶基-CCNU；将它们的活性与卡氮芥、洛莫司汀、司莫司汀和羟乙基-CCNU进行比较。所有测试化合物均表现出或多或少明显的化疗活性。司莫司汀优于所有其他研究的化合物。讨论了从对亚硝基脲类高度敏感的模型获得的结果对人类肿瘤的预测价值。
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