Division of Rheumatology, David Geffen School of Medicine, UCLA, 1000 Veteran Avenue Room 32-59, Los Angeles, CA 90095-1670, USA.
Curr Rheumatol Rep. 2012 Oct;14(5):455-62. doi: 10.1007/s11926-012-0271-5.
Patients with rheumatoid arthritis (RA) suffer significantly increased cardiovascular (CV) morbidity and mortality, when compared with the general population. Both traditional CV risk factors and high levels of systemic inflammation have been linked to the increased CV risk in RA patients, but significant uncertainty remains regarding the mechanisms through which these factors contribute to CV disease (CVD). In addition, ongoing questions remain regarding how best to identify RA patients at high risk for CVD and what primary and secondary prevention strategies are effective at influencing CV outcome. The present review summarizes recent research in this field.
类风湿关节炎（RA）患者的心血管（CV）发病率和死亡率明显高于普通人群。传统的 CV 危险因素和高水平的全身炎症与 RA 患者的 CV 风险增加有关，但这些因素如何导致 CVD 的机制仍存在很大的不确定性。此外，关于如何最好地识别 CVD 风险高的 RA 患者以及哪些一级和二级预防策略对 CV 结局有效的问题仍存在争议。本综述总结了该领域的最新研究。
