Division of Plastic Surgery, Department of Surgery, University of Washington, Seattle, Washington, United States of America.
PLoS One. 2012;7(7):e40086. doi: 10.1371/journal.pone.0040086. Epub 2012 Jul 5.
Burn demographics, prevention and care have changed considerably since the 1970s. The objectives were to 1) identify new and confirm previously described changes, 2) make comparisons to the American Burn Association National Burn Repository, 3) determine when the administration of fluids in excess of the Baxter formula began and to identify potential causes, and 4) model mortality over time, during a 36-year period (1974-2009) at the Harborview Burn Center in Seattle, WA, USA.
14,266 consecutive admissions were analyzed in five-year periods and many parameters compared to the National Burn Repository. Fluid resuscitation was compared in five-year periods from 1974 to 2009. Mortality was modeled with the rBaux model. Many changes are highlighted at the end of the manuscript including 1) the large increase in numbers of total and short-stay admissions, 2) the decline in numbers of large burn injuries, 3) that unadjusted case fatality declined to the mid-1980s but has changed little during the past two decades, 4) that race/ethnicity and payer status disparity exists, and 5) that the trajectory to death changed with fewer deaths occurring after seven days post-injury. Administration of fluids in excess of the Baxter formula during resuscitation of uncomplicated injuries was evident at least by the early 1990s and has continued to the present; the cause is likely multifactorial but pre-hospital fluids, prophylactic tracheal intubation and opioids may be involved.
自 20 世纪 70 年代以来,烧伤患者的人群特征、预防措施和治疗方式发生了巨大变化。本研究旨在:1)发现新的变化并确认以前描述过的变化;2)与美国烧伤协会国家烧伤资料库进行比较;3)确定开始使用超过 Baxter 公式的补液量的时间,并确定潜在原因;4)在美国华盛顿州西雅图的 Harborview 烧伤中心,对 1974 年至 2009 年 36 年间的死亡率进行建模。
对连续 14266 例患者进行了 5 年为一个阶段的分析,并与国家烧伤资料库中的许多参数进行了比较。比较了 1974 年至 2009 年的五个时间段内的液体复苏情况。采用 rBaux 模型对死亡率进行建模。在文章结尾处突出显示了许多变化,包括:1)总住院人数和短住住院人数大量增加;2)大面积烧伤患者数量减少;3)未经调整的病死率在 20 世纪 80 年代中期有所下降,但在过去 20 年中几乎没有变化;4)种族/民族和支付者状况存在差异;5)死亡轨迹发生变化,受伤后 7 天内死亡人数减少。在复苏非复杂性损伤时使用超过 Baxter 公式的补液在 20 世纪 90 年代初就已存在,并一直持续到现在;原因可能是多方面的,但院前补液、预防性气管插管和阿片类药物可能参与其中。
1)显著变化包括短住患者的增加;因此,自 20 世纪 70 年代以来实行的烧伤治疗模式仍然需要,但已经不够了。2)在非复杂性损伤时使用超过 Baxter 公式的补液至少在 20 年前就开始了。3)未经调整的病死率在 20 世纪 80 年代中期下降到约 6%,此后变化不大。rBaux 死亡率模型非常准确。