• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

强心剂的研究。II. 新型酞嗪和1,2,3-苯并三嗪衍生物的合成。

Studies on cardiotonic agents. II. Synthesis of novel phthalazine and 1,2,3-benzotriazine derivatives.

作者信息

Nomoto Y, Obase H, Takai H, Teranishi M, Nakamura J, Kubo K

机构信息

Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd., Japan.

出版信息

Chem Pharm Bull (Tokyo). 1990 Aug;38(8):2179-83. doi: 10.1248/cpb.38.2179.

DOI:10.1248/cpb.38.2179
PMID:2279280
Abstract

A series of phthalazine and 1,2,3-benzotriazine derivatives which have heterocyclylpiperidino groups was synthesized and tested for cardiotonic activity in anesthetized dogs. Several 6,7-dimethoxyphthalazine derivatives showed relatively potent cardiotonic activity comparable to that of amrinone.

摘要

合成了一系列带有杂环基哌啶基的酞嗪和1,2,3-苯并三嗪衍生物，并在麻醉犬身上测试了它们的强心活性。几种6,7-二甲氧基酞嗪衍生物显示出相对较强的强心活性，与氨力农相当。

相似文献

1
Studies on cardiotonic agents. II. Synthesis of novel phthalazine and 1,2,3-benzotriazine derivatives.强心剂的研究。II. 新型酞嗪和1,2,3-苯并三嗪衍生物的合成。
Chem Pharm Bull (Tokyo). 1990 Aug;38(8):2179-83. doi: 10.1248/cpb.38.2179.
2
Preparation of 1-(1,4,5,6-tetrahydro-1,2,4-triazinyl)phthalazine derivatives possessing antihypertensive properties.具有抗高血压特性的1-(1,4,5,6-四氢-1,2,4-三嗪基)酞嗪衍生物的制备
Acta Pol Pharm. 1984;41(4):405-10.
3
Studies on cardiotonic agents. I. Synthesis of some quinazoline derivatives.
Chem Pharm Bull (Tokyo). 1990 Jun;38(6):1591-5. doi: 10.1248/cpb.38.1591.
4
Synthesis and anti-inflammatory activity evaluation of some novel 6-alkoxy(phenoxy)-[1,2,4]triazolo[3,4-a]phthalazine-3-amine derivatives.一些新型 6-烷氧基（苯氧基）-[1,2,4]三唑并[3,4-a]酞嗪-3-胺衍生物的合成及抗炎活性评价。
Eur J Med Chem. 2010 Nov;45(11):4807-12. doi: 10.1016/j.ejmech.2010.07.049. Epub 2010 Aug 6.
5
Synthesis and antibacterial activity of some new heterocycles incorporating phthalazine.合成及一些新的杂环包含酞嗪的抗菌活性。
Eur J Med Chem. 2009 Nov;44(11):4448-54. doi: 10.1016/j.ejmech.2009.06.003. Epub 2009 Jun 13.
6
Synthesis and antimicrobial activities of novel 1,2,4-triazolo [3,4-a] phthalazine derivatives.新型 1,2,4-三唑并[3,4-a]邻苯二甲酰亚胺衍生物的合成及抗菌活性。
Bioorg Med Chem Lett. 2014 Feb 15;24(4):1236-8. doi: 10.1016/j.bmcl.2013.12.010. Epub 2013 Dec 7.
7
Synthesis and positive inotropic evaluation of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted piperazine moieties.含取代哌嗪基团的[1,2,4]三唑并[3,4-a]酞嗪和四唑并[5,1-a]酞嗪衍生物的合成及正性肌力评价
Bioorg Med Chem Lett. 2014 Apr 1;24(7):1737-41. doi: 10.1016/j.bmcl.2014.02.040. Epub 2014 Mar 3.
8
Synthesis and antitumor activities of novel 1,4-disubstituted phthalazine derivatives.新型 1,4-取代邻苯二甲酰亚胺衍生物的合成及抗肿瘤活性研究。
Eur J Med Chem. 2010 Aug;45(8):3504-10. doi: 10.1016/j.ejmech.2010.05.016. Epub 2010 May 12.
9
Synthesis and anti-inflammatory activity evaluation of a novel series of 6-phenoxy-[1,2,4]triazolo[3,4-a]phthalazine-3-carboxamide derivatives.新型6-苯氧基-[1,2,4]三唑并[3,4-a]酞嗪-3-甲酰胺衍生物的合成及抗炎活性评价
Bioorg Med Chem Lett. 2016 Mar 15;26(6):1576-1579. doi: 10.1016/j.bmcl.2016.02.008. Epub 2016 Feb 4.
10
Synthesis and biological evaluation of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted benzylpiperazine moieties as positive inotropic agents.含取代苄基哌嗪结构的[1,2,4]三唑并[3,4-a]酞嗪和四唑并[5,1-a]酞嗪衍生物的合成及作为正性肌力药物的生物评价。
Chem Biol Drug Des. 2013 May;81(5):591-9. doi: 10.1111/cbdd.12101. Epub 2013 Mar 26.

引用本文的文献

1
Novel L-tryptophan-functionalized zirconium dioxide nanoparticles catalysed one-pot and solvent-free synthesis of 2 H-indazolo [2, 1-b] phthalazine-triones.新型L-色氨酸功能化二氧化锆纳米颗粒催化一锅法无溶剂合成2H-吲唑并[2,1-b]酞嗪三酮。
Sci Rep. 2025 Jul 13;15(1):25323. doi: 10.1038/s41598-025-11227-z.
2
Rational design, synthesis, in vitro, and in-silico studies of pyrazole‑phthalazine hybrids as new α‑glucosidase inhibitors.吡唑-酞嗪杂化物作为新型α-葡萄糖苷酶抑制剂的合理设计、合成、体外及计算机模拟研究
Sci Rep. 2025 Jan 30;15(1):3744. doi: 10.1038/s41598-025-87258-3.
3
Preparation, characterization, and use of novel Cu@FeO MNPs in the synthesis of tetrahydrobenzimidazo[2,1-]quinazolin-1(2)-ones and 2-indazolo[2,1-]phthalazine-triones under solvent-free conditions.
新型铜包铁磁性纳米粒子在无溶剂条件下合成四氢苯并咪唑并[2,1 - ]喹唑啉 - 1(2) - 酮和2 - 吲唑并[2,1 - ]酞嗪 - 三酮中的制备、表征及应用
RSC Adv. 2019 May 14;9(26):15061-15072. doi: 10.1039/c9ra01509d. eCollection 2019 May 9.
4
Amino- and polyaminophthalazin-1(2)-ones: synthesis, coordination properties, and biological activity.氨基和多氨基酞嗪-1(2)-酮：合成、配位性质及生物活性
Beilstein J Org Chem. 2021 Feb 25;17:558-568. doi: 10.3762/bjoc.17.50. eCollection 2021.
5
Crystal structure of 13-phenyl-2,3,4,13-tetra-hydro-1H-indazolo[1,2-b]phthalazine-1,6,11-trione.13-苯基-2,3,4,13-四氢-1H-吲唑并[1,2-b]酞嗪-1,6,11-三酮的晶体结构
Acta Crystallogr E Crystallogr Commun. 2015 Dec 12;71(Pt 12):o1036-7. doi: 10.1107/S2056989015023452. eCollection 2015 Dec 1.
6
Crystal structure of 13-(2-meth-oxy-phenyl)-3,4-di-hydro-2H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione.13-(2-甲氧基苯基)-3,4-二氢-2H-吲唑并[1,2-b]酞嗪-1,6,11(13H)-三酮的晶体结构
Acta Crystallogr E Crystallogr Commun. 2015 Jul 25;71(Pt 8):o604-5. doi: 10.1107/S2056989015013894. eCollection 2015 Aug 1.
7
Combining click-multicomponent reaction: one-pot synthesis of triazolyl methoxy-phenyl indazolo[2,1-b]phthalazine-trione derivatives.结合点击多组分反应：一锅法合成三唑基甲氧基-苯基吲唑并[2,1-b]酞嗪-1,3-二酮衍生物。
Mol Divers. 2012 May;16(2):231-40. doi: 10.1007/s11030-011-9348-8. Epub 2011 Dec 11.