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人类组织中含有 CD141hi 交叉呈递树突状细胞，其功能与小鼠 CD103+ 非淋巴样树突状细胞具有同源性。

Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells.

机构信息

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

出版信息

Immunity. 2012 Jul 27;37(1):60-73. doi: 10.1016/j.immuni.2012.04.012. Epub 2012 Jul 12.

DOI:10.1016/j.immuni.2012.04.012
PMID:22795876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3476529/
Abstract

Dendritic cell (DC)-mediated cross-presentation of exogenous antigens acquired in the periphery is critical for the initiation of CD8(+) T cell responses. Several DC subsets are described in human tissues but migratory cross-presenting DCs have not been isolated, despite their potential importance in immunity to pathogens, vaccines, and tumors and tolerance to self. Here, we identified a CD141(hi) DC present in human interstitial dermis, liver, and lung that was distinct from the majority of CD1c(+) and CD14(+) tissue DCs and superior at cross-presenting soluble antigens. Cutaneous CD141(hi) DCs were closely related to blood CD141(+) DCs, and migratory counterparts were found among skin-draining lymph node DCs. Comparative transcriptomic analysis with mouse showed tissue DC subsets to be conserved between species and permitted close alignment of human and mouse DC subsets. These studies inform the rational design of targeted immunotherapies and facilitate translation of mouse functional DC biology to the human setting.

摘要

树突状细胞 (DC) 介导的外周源性外源抗原交叉呈递对于 CD8(+) T 细胞反应的启动至关重要。在人类组织中描述了几种 DC 亚群，但迁移性交叉呈递 DC 尚未被分离，尽管它们在病原体、疫苗和肿瘤的免疫以及对自身的耐受中具有重要意义。在这里，我们鉴定了一种存在于人类间质真皮、肝脏和肺部的 CD141(hi) DC，它与大多数 CD1c(+) 和 CD14(+) 组织 DC 不同，并且在交叉呈递可溶性抗原方面具有优势。皮肤 CD141(hi) DC 与血液 CD141(+) DC 密切相关，在皮肤引流淋巴结 DC 中发现了迁移的对应物。与小鼠的比较转录组学分析表明，组织 DC 亚群在物种间是保守的，并允许人类和小鼠 DC 亚群的紧密对齐。这些研究为有针对性的免疫治疗的合理设计提供了信息，并促进了小鼠功能 DC 生物学向人类环境的转化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ed/3476529/fab98d1ec7f9/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ed/3476529/8811d01be4e0/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ed/3476529/85abca3eae2e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ed/3476529/49fa1e426a1b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ed/3476529/7abf1befbea9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ed/3476529/dca501a7f505/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ed/3476529/6fbb792cf423/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ed/3476529/cc448f6b1a9f/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ed/3476529/fab98d1ec7f9/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ed/3476529/8811d01be4e0/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ed/3476529/85abca3eae2e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ed/3476529/49fa1e426a1b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ed/3476529/7abf1befbea9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ed/3476529/dca501a7f505/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ed/3476529/6fbb792cf423/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ed/3476529/cc448f6b1a9f/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ed/3476529/fab98d1ec7f9/gr7.jpg

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本文引用的文献

[1]
Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation.

J Exp Med. 2012-4-30

[2]
Characterization of resident and migratory dendritic cells in human lymph nodes.

J Exp Med. 2012-3-19

[3]
Dendritic cell-associated lectin 2 (DCAL2) defines a distinct CD8α- dendritic cell subset.

J Leukoc Biol. 2011-12-6

[4]
Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.

Immunity. 2011-10-20

[5]
Cutting edge: expression of XCR1 defines mouse lymphoid-tissue resident and migratory dendritic cells of the CD8α+ type.

J Immunol. 2011-9-23

[6]
Human dendritic cell deficiency: the missing ID?

Nat Rev Immunol. 2011-8-19

[7]
Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4⁺ T cells but are incapable of cross-presentation.

Eur J Immunol. 2011-8-8

[8]
Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-β1-dependent human epidermal Langerhans cells.

J Invest Dermatol. 2011-6-16

[9]
Human dendritic cell subsets from spleen and blood are similar in phenotype and function but modified by donor health status.

J Immunol. 2011-4-22

[10]
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates.

Proc Natl Acad Sci U S A. 2011-4-5

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