肿瘤相关基因 IL-10、PSCA、MTRR 和 NOC3L 的多态性与中国汉族人群胃癌的发病风险相关。

Polymorphisms of tumor-related genes IL-10, PSCA, MTRR and NOC3L are associated with the risk of gastric cancer in the Chinese Han population.

机构信息

Department of General Surgery, Tangdu Hospital of the Fourth Military Medical University, Xi'an, Shaanxi 710038, China.

出版信息

Cancer Epidemiol. 2012 Dec;36(6):e366-72. doi: 10.1016/j.canep.2012.05.016. Epub 2012 Jul 15.

DOI:10.1016/j.canep.2012.05.016

PMID:22796266

Abstract

BACKGROUND

Gastric cancer is the fourth most common cancer in the world. Environmental and genetic factors both play critical roles in the etiology of gastric cancer. Hundreds of SNPs have been identified to have association with the risk of gastric cancer in many races. In this study, 25 SNPs in genes for IL-10, IL-1B, MTRR, TNF-а, PSCA, PLCE1 and NOC3L were analyzed to further evaluate their associations with gastric cancer susceptibility in the Chinese Han population.

METHODS

Two hundred and seventy nine gastric cancer patients and 296 healthy controls were recruited in this study. SNP genotyping was conducted using Sequenom MassARRAY RS1000. Data management and statistical analyses were conducted by Sequenom Typer 4.0 Software and Pearson's χ(2) test.

RESULTS

One protective allele and three risk alleles for gastric cancer patients were found in this study. The allele "G" of rs1801394 in MTRR showed an association with a decreased risk of gastric cancer: odds ratio (OR) = 0.74, 95% confidence interval (95% CI) = 0.57-0.97, P = 0.030 in the additive model; OR = 0.495, 95% CI = 0.26-0.95, P = 0.034 in the recessive model. The other three SNPs, the allele "C" of rs1800871 in IL10 (OR = 1.33, 95% CI = 1.04-1.90; P = 0.026 in the additive model; OR = 1.46, 95% CI = 1.04-2.06; P = 0.030 in the recessive model), the allele "A" of rs2976391 in PSCA (OR = 1.30, 95% CI = 1.01-1.66; P = 0.041 in the additive model and OR = 1.48, 95% CI = 1.04-2.11, P = 0.028 in the recessive model), and the allele "G" of rs17109928 in NOC3L gene (OR = 1.34, 95% CI = 1.01-1.78; P = 0.042 by additive model analysis; OR = 1.47, 95% CI = 1.04-2.07, P = 0.028 by dominant model analysis), showed an association with an increased risk of gastric cancer.

CONCLUSIONS

These results indicate the importance of four gastric cancer susceptibility polymorphisms of IL-10, NOC3L, PSCA and MTRR in the Chinese Han population, which could be used in the determination of gastric cancer risk in clinical practice.

摘要

背景

胃癌是世界上第四大常见癌症。环境和遗传因素都在胃癌的发病机制中起着关键作用。在许多种族中，已有数百个 SNP 被发现与胃癌风险相关。在这项研究中，分析了 IL-10、IL-1B、MTRR、TNF-а、PSCA、PLCE1 和 NOC3L 基因中的 25 个 SNP，以进一步评估它们与中国汉族人群胃癌易感性的关系。

方法

本研究纳入了 279 名胃癌患者和 296 名健康对照者。使用 Sequenom MassARRAY RS1000 进行 SNP 基因分型。数据管理和统计分析由 Sequenom Typer 4.0 软件和 Pearson χ(2)检验完成。

结果

本研究发现了一个胃癌患者的保护性等位基因和三个风险等位基因。MTRR 基因 rs1801394 的等位基因“G”与胃癌风险降低相关：加性模型中，比值比（OR）=0.74，95%置信区间（95%CI）=0.57-0.97，P=0.030；隐性模型中，OR=0.495，95%CI=0.26-0.95，P=0.034。其他三个 SNP，IL10 基因 rs1800871 的等位基因“C”（加性模型中，OR=1.33，95%CI=1.04-1.90；P=0.026；隐性模型中，OR=1.46，95%CI=1.04-2.06；P=0.030）、PSCA 基因 rs2976391 的等位基因“G”（加性模型中，OR=1.30，95%CI=1.01-1.66；P=0.041；隐性模型中，OR=1.48，95%CI=1.04-2.11，P=0.028）和 NOC3L 基因 rs17109928 的等位基因“G”（加性模型中，OR=1.34，95%CI=1.01-1.78；P=0.042；显性模型中，OR=1.47，95%CI=1.04-2.07，P=0.028），与胃癌风险增加相关。