Ruhr-Universität Bochum, Institut für Physiologische Chemie, Universitätsstrasse 150, D-44780 Bochum, Germany.
Microbes Infect. 2012 Oct;14(12):1026-33. doi: 10.1016/j.micinf.2012.07.002. Epub 2012 Jul 14.
The vacuolating cytotoxin VacA, a polypeptide of about 88 kDa, is one of the major virulence factors of Helicobacter pylori. VacA essentially acts as an invasive chloride channel targeting mitochondria. The results of recent studies open a new perspective on the mechanisms by which VacA causes loss of the mitochondrial membrane potential, mitochondrial fragmentation, formation of reactive oxygen species, autophagy, cell death and gastric cancer.
空泡细胞毒素 VacA 是一种约 88 kDa 的多肽，是幽门螺杆菌的主要毒力因子之一。VacA 主要作为一种靶向线粒体的侵袭性氯离子通道发挥作用。最近的研究结果为 VacA 导致线粒体膜电位丧失、线粒体碎片化、活性氧形成、自噬、细胞死亡和胃癌的机制提供了新的视角。
