Laboratório de Microbiologia Experimental e Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
Brain Res. 2012 Aug 30;1471:162-8. doi: 10.1016/j.brainres.2012.06.054. Epub 2012 Jul 11.
Neonatal meningitis is an illness characterized by inflammation of the meninges and occurring within the birth and the first 28 days of life. Invasive infection by Streptococcus pneumoniae, meningitis and sepsis, in neonate is associated with prolonged rupture of membranes; maternal colonization/illness, prematurity, high mortality and 50% of cases have some form of disability. For this purpose, we measured brain levels of TNF-α, IL-1β, IL-6, IL-10, CINC-1, oxidative damage, enzymatic defense activity and the blood-brain barrier (BBB) integrity in neonatal Wistar rats submitted to pneumococcal meningitis. The cytokines increased prior to the BBB breakdown and this breakdown occurred in the hippocampus at 18 h and in the cortex at 12h after pneumococcal meningitis induction. The time-dependent association between the complex interactions among cytokines, chemokine may be responsible for the BBB breakdown and neonatal pneumococcal severity.
新生儿脑膜炎是一种脑膜炎症性疾病，发生在出生后和生命的头 28 天内。侵袭性感染肺炎链球菌、脑膜炎和败血症与胎膜早破时间延长、产妇定植/患病、早产、高死亡率有关，50%的病例有某种形式的残疾。为此，我们测量了新生儿 Wistar 大鼠肺炎球菌性脑膜炎时大脑中 TNF-α、IL-1β、IL-6、IL-10、CINC-1、氧化损伤、酶防御活性和血脑屏障（BBB）完整性的水平。细胞因子在 BBB 破裂前增加，这种破裂发生在诱导肺炎球菌性脑膜炎后 18 小时的海马体和 12 小时的皮质。细胞因子、趋化因子之间的复杂相互作用的时间依赖性关联可能是 BBB 破裂和新生儿肺炎球菌严重程度的原因。
