Eishi Y, McCullagh P
Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra.
Scand J Immunol. 1988 Jun;27(6):629-34. doi: 10.1111/j.1365-3083.1988.tb02395.x.
The susceptibility to experimental allergic thyroiditis (EAT) of rats that had previously been immunized against thyroglobulin was examined. Challenge with thyroglobulin 5 weeks previously conferred strong resistance to the induction of EAT after exposure to a sensitization protocol that was otherwise highly effective. Resistance to induction of EAT could also be conferred by the inoculation of spleen cells from thyroglobulin-sensitized donors on the day of birth. Heavily irradiated spleen cells from sensitized donors were able to confer resistance on neonatal recipients, indicating that prolonged survival of the transferred cells was not required.
对先前已针对甲状腺球蛋白进行免疫的大鼠的实验性过敏性甲状腺炎（EAT）易感性进行了检测。5周前用甲状腺球蛋白激发，使大鼠在暴露于原本高效的致敏方案后，对EAT的诱导产生了强烈抗性。在出生当天接种来自甲状腺球蛋白致敏供体的脾细胞，也能赋予对EAT诱导的抗性。来自致敏供体的经过大量辐照的脾细胞能够使新生受体产生抗性，这表明转移细胞并不需要长期存活。
