一名患有1型糖尿病且面色发黄的女孩。
A girl with type 1 diabetes and a yellowish appearance.
作者信息
Hovinga I C L Kremer, Stam E D, Mearin M L, Mul D
机构信息
Department of Pediatrics, 't Lange Land Hospital, Zoetermeer, The Netherlands.
出版信息
BMJ Case Rep. 2010 Nov 26;2010:bcr0420102899. doi: 10.1136/bcr.04.2010.2899.
Type 1 diabetes mellitus in children has been associated with other autoimmune diseases, especially coeliac disease and autoimmune thyroiditis. This association may be the result of a common pathogenic background. We describe the case of a girl with type 1 diabetes mellitus who developed icterus due to autoimmune hepatitis, a disease rarely found in children. Thyroiditis-associated and diabetes-associated autoantibodies were also present. Human leucocyte antigen typing revealed DRB1*03 heterozygosity, which has been associated with the occurrence of both autoimmune hepatitis and type 1 diabetes. This finding implies that similar pathogenic pathways may be involved in different autoimmune diseases including type 1 diabetes and autoimmune hepatitis. The patient was successfully treated with prednisolone and azathioprine. Autoimmune hepatitis can be a serious co-occurring disease in patients with type 1 diabetes.
儿童1型糖尿病与其他自身免疫性疾病有关，尤其是乳糜泻和自身免疫性甲状腺炎。这种关联可能是共同致病背景的结果。我们描述了一名患有1型糖尿病的女孩的病例，她因自身免疫性肝炎出现黄疸，这种疾病在儿童中很少见。还存在与甲状腺炎相关和与糖尿病相关的自身抗体。人类白细胞抗原分型显示为DRB1*03杂合性，这与自身免疫性肝炎和1型糖尿病的发生都有关。这一发现表明，包括1型糖尿病和自身免疫性肝炎在内的不同自身免疫性疾病可能涉及相似的致病途径。该患者接受泼尼松龙和硫唑嘌呤治疗成功。自身免疫性肝炎可能是1型糖尿病患者中严重的并发疾病。
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