Bawahab Noor S, Safdar Osama Y, Nagadi Sarah A, Saeedi Asalh T, Mohammed Hussain Raghad W
Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Pediatric Nephrology Center of Excellence, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
SAGE Open Med Case Rep. 2019 Jan 31;7:2050313X19827734. doi: 10.1177/2050313X19827734. eCollection 2019.
Occurrence of early nephrotic syndrome in type 1 diabetes mellitus patients is extremely rare. Herein, we report the case of a 12-year-old boy who presented to our pediatric nephrology clinic with generalized edema. He had been diagnosed with type 1 diabetes mellitus at age 9 and had been treated with regular insulin. Examinations revealed normal kidney function, hypoalbuminemia, proteinuria (4+), hyperlipidemia, and low protein-to-creatinine ratio. The patient was diagnosed with idiopathic nephrotic syndrome and was empirically administered prednisolone for 12 weeks. Subsequently, prednisolone was tapered over 10-12 weeks. The patient showed good response to treatment. In conclusion, co-existence of nephrotic syndrome and type 1 diabetes mellitus may suggest an immunological basis; therefore, further studies are needed to investigate the relationship between these two conditions.
1型糖尿病患者早期肾病综合征的发生极为罕见。在此，我们报告一例12岁男孩的病例，该男孩因全身水肿就诊于我们的儿科肾脏病诊所。他9岁时被诊断为1型糖尿病，一直接受常规胰岛素治疗。检查发现肾功能正常、低蛋白血症、蛋白尿（4+）、高脂血症以及低蛋白与肌酐比值。该患者被诊断为特发性肾病综合征，并经验性给予泼尼松龙治疗12周。随后，泼尼松龙在10 - 12周内逐渐减量。患者对治疗反应良好。总之，肾病综合征与1型糖尿病并存可能提示存在免疫基础；因此，需要进一步研究来探讨这两种情况之间的关系。
