Behera B C, Bhunya S P
P.G. Department of Zoology, Utkal University, Bhubaneswar, India.
Indian J Exp Biol. 1990 Sep;28(9):862-7.
Genotoxic effect of isoproturon was assessed by employing in vivo chromosomal aberration, micronucleus and sperm-shape abnormality assays. A significant dose-responsive mutagenic effect was observed in chromosome aberration and sperm-shape abnormality tests whereas in micronucleus assay the effect was significant only at the highest dose (200 mg/kg). Only the result for the chronic dose and the two different fixation times (6 and 48 hr) were not statistically significant. The results indicate the genotoxic property of isoproturon in mammalian in vivo test system.
通过体内染色体畸变、微核和精子形态异常试验评估异丙隆的遗传毒性作用。在染色体畸变和精子形态异常试验中观察到显著的剂量反应诱变效应，而在微核试验中，仅在最高剂量（200mg/kg）时效应显著。只有慢性剂量以及两种不同固定时间（6小时和48小时）的结果无统计学意义。结果表明异丙隆在哺乳动物体内试验系统中具有遗传毒性。
