Pal B B, Bhunya S P
P.G. Department of Zoology, Utkal University, Orissa, India.
In Vivo. 1995 Jan-Feb;9(1):81-3.
The genotoxic potential of zinctox (zinc phosphide) was evaluated in mice in vivo employing different bioassays: bone marrow chromosome aberration, micronucleus and sperm shape abnormality. A significant increase of chromosome aberrations was induced by three doses. Interestingly, the highest percentage was induced by the middle dose. In a route-responsive study the highest percentage of chromosome aberration was induced by the oral route. A dose-dependent increase in the incidence of micronuclei was noticed in the bone marrow cells. In the sperm shape abnormality test a high percentage of abnormal sperm was induced by all three dose levels. The results revealed the genotoxic potential of zinctox in the tested mouse in vivo system.
骨髓染色体畸变、微核和精子形态异常。三个剂量均诱导染色体畸变显著增加。有趣的是，中间剂量诱导的百分比最高。在一项途径反应性研究中，口服途径诱导的染色体畸变百分比最高。在骨髓细胞中观察到微核发生率呈剂量依赖性增加。在精子形态异常试验中，所有三个剂量水平均诱导出高百分比的异常精子。结果揭示了磷化锌在受试小鼠体内系统中的遗传毒性潜力。
