Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
J Nat Med. 2013 Apr;67(2):327-32. doi: 10.1007/s11418-012-0686-3. Epub 2012 Jul 15.
Euphorbia microsciadia (Euphorbiaceae) is a perennial plant growing in Iran. Two new cyclomyrsinol esters, 3-O-propionyl-5, 10, 14-O-triacetyl-8-O-(2'-methyl-butanoyl)-cyclomyrsinol (1) and 3, 5, 10, 14, 15-O-pentaacetyl-8-O-isobutanoyl-cyclomyrsinol (2) were isolated from the methanolic extract of its dried aerial parts. The structures were elucidated based on (13)C- and (1)H-NMR as well as 2D-NMR, IR and different MS spectra. Anti-angiogenic activity was also evaluated on vascular endothelium growth factor (VEGF)-induced angiogenesis in cultured human umbilical vein endothelial cells in vitro by assessing capillary-like tube network formation.
大飞扬草（大戟科）是一种在伊朗生长的多年生植物。从其干燥地上部分的甲醇提取物中分离得到了两种新的环牧脂醇酯：3-O-丙酰基-5,10,14-O-三乙酰基-8-O-（2'-甲基丁酰基）-环牧脂醇（1）和 3,5,10,14,15-O-五乙酰基-8-O-异丁酰基-环牧脂醇（2）。根据 13C-NMR 和 1H-NMR 以及二维 NMR、IR 和不同的 MS 谱确定了它们的结构。还通过评估体外培养的人脐静脉内皮细胞中血管内皮生长因子（VEGF）诱导的血管生成中毛细血管样管状网络形成，评估了它们的抗血管生成活性。
