酒精特异性父母规则设定对多巴胺 D2 受体基因 (DRD2)、μ-阿片受体基因 (OPRM1) 和青少年饮酒之间关系的调节作用。
The moderating effect of alcohol-specific parental rule-setting on the relation between the dopamine D2 receptor gene (DRD2), the μ-opioid receptor gene (OPRM1) and alcohol use in young adolescents.
机构信息
Radboud University Nijmegen, Behavioural Science Insititute, PO Box 9104, 6500 HE Nijmegen, The Netherlands.
出版信息
Alcohol Alcohol. 2012 Nov-Dec;47(6):663-70. doi: 10.1093/alcalc/ags075. Epub 2012 Jul 12.
AIMS
The main aim of the study was to test the moderating effect of two genetic polymorphisms, one in the dopamine D2 receptor gene (DRD2) and one in the mu-opioid receptor gene (OPRM1), on the link between parental rule-setting and adolescent alcohol use.
METHODS
A total of 214 adolescents (M(age )=13.7, 44.9% male) provided saliva samples and completed survey items describing alcohol use and parental rule-setting.
RESULTS
Findings indicated that alcohol-specific parental rule-setting was more robustly associated with alcohol use for adolescents with the DRD2 A1 risk allele and for those with the OPRM1 G-allele.
CONCLUSION
This study replicates the interaction between parental rule-setting and the DRD2 risk allele on adolescent alcohol use and extends the literature by demonstrating the moderating effects of the OPRM1 risk allele on the link between parental rule-setting and adolescent alcohol use.
目的
本研究的主要目的是检验两种遗传多态性（一种在多巴胺 D2 受体基因（DRD2）中，一种在μ-阿片受体基因（OPRM1）中）对父母规则制定与青少年饮酒之间关系的调节作用。
方法
共有 214 名青少年（M（年龄）=13.7，44.9%为男性）提供了唾液样本，并完成了描述饮酒和父母规则制定的调查项目。
结果
研究结果表明，对于携带 DRD2 A1 风险等位基因的青少年和携带 OPRM1 G-等位基因的青少年，特定于酒精的父母规则制定与饮酒之间的关系更为密切。
结论
本研究复制了父母规则制定与 DRD2 风险等位基因对青少年饮酒的相互作用，并通过证明 OPRM1 风险等位基因对父母规则制定与青少年饮酒之间关系的调节作用，扩展了文献。
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