检测厌氧菌对美罗培南敏感性的质量控制标准。
Quality control criteria for testing the susceptibility of anaerobic bacteria to meropenem.
作者信息
Zabransky R J, Bayola-Mueller L, Jenkins S G, Pitkin D R, Schreckenberger P C, Celig D M, Spiegel C A
机构信息
Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Sinai Samaritan Medical Center, Milwaukee 53201.
出版信息
J Clin Microbiol. 1990 Dec;28(12):2804-5. doi: 10.1128/jcm.28.12.2804-2805.1990.
Reference values for quality control of in vitro susceptibility tests with meropenem against anaerobic bacteria were determined in a multilaboratory study by the approved National Committee for Clinical Laboratory Standards agar dilution method for the four quality control strains. The study protocol also included the evaluation of microdilution testing, medium additives, and multiple lots of media. The recommended MIC control ranges for three of the control organisms are as follows: Bacteroides fragilis ATCC 25285, 0.06 to 0.125 micrograms/ml; Bacteroides thetaiotaomicron ATCC 29741, 0.125 to 0.5 micrograms/ml; and Eubacterium lentum ATCC 43055, 0.125 to 0.5 micrograms/ml. The modal MIC for Clostridium perfringens ATCC 13124 was at or below the lowest concentration of meropenem tested, and no values are recommended.
通过美国国家临床实验室标准委员会批准的琼脂稀释法，在一项多实验室研究中确定了美罗培南对厌氧菌体外药敏试验的质量控制参考值，该方法用于四种质量控制菌株。研究方案还包括对微量稀释试验、培养基添加剂和多批培养基的评估。三种对照菌的推荐 MIC 控制范围如下：脆弱拟杆菌 ATCC 25285，0.06 至 0.125 微克/毫升；多形拟杆菌 ATCC 29741，0.125 至 0.5 微克/毫升；迟缓真杆菌 ATCC 43055，0.125 至 0.5 微克/毫升。产气荚膜梭菌 ATCC 13124 的模态 MIC 处于或低于所测试的美罗培南最低浓度，因此不推荐给出具体数值。
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