乙型肝炎病毒在人脾脏内的复制。
Hepatitis B virus replication within the human spleen.
作者信息
Di Bisceglie A M, Hoofnagle J H
机构信息
Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892.
出版信息
J Clin Microbiol. 1990 Dec;28(12):2850-2. doi: 10.1128/jcm.28.12.2850-2852.1990.
Abstract
Southern blot analysis of splenic DNA from three patients with chronic hepatitis B revealed the presence of replicative intermediate forms of viral DNA. Hepatitis B viral RNA was detected in splenic RNA from two cases. Thus, hepatitis B virus appears to replicate in the human spleen, although at a lower level than in the liver.
摘要
对三名慢性乙型肝炎患者脾脏DNA进行的Southern印迹分析显示存在病毒DNA的复制中间形式。在两例患者的脾脏RNA中检测到乙型肝炎病毒RNA。因此，乙型肝炎病毒似乎在人类脾脏中复制，尽管其水平低于在肝脏中的复制水平。
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