Wang Guang-lu, Wang Ming-yang, Wei Wen-bin
Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. continent
Zhonghua Yan Ke Za Zhi. 2012 Apr;48(4):318-22.
To study the effects of transpupillary thermotherapy (TTT) on circumscribed choroidal hemangiomas (CCH).
It was a retrospective cases series study. One hundred and fourteen cases (114 eyes) in out-patient department were enrolled in the study with 80 male cases and 34 female cases. The age ranged from 16 to 71 yrs with an average at 44 years. Single eye was affected in all cases. Indirect ophthalmoscope, fundus fluorescein angiography (FFA), ultrasound (B) were used for the examination. Treatment was delivered via slit lamp by using an 810 nm diode laser (Irises) with spots or composed spots (larger tumor) covering the whole tumor. If the tumor was located or partly located in the fovea, laser spot should be avoided in the fovea and papillo-macular bundle. The laser power should be lesser (light gray color) in parafovea area. Routine laser spot (gray-white color) was used in perifovea area. A width of 200 µm out of disk border should not be placed by laser spot in paradisk tumor cases.
The visual acuity (VA) ≥ 0.5 of pre-and post-treatment was 17 eyes (14.9%) and 27 eyes (23.7%), respectively. Pre-treatment, the retinal detachment extended in the inferior part in 27 cases (23.7%) except on the tumor surface. The tumor was located at macular area in 67 cases (58.8%), around the disc in 35 cases (30.7%), at the temporal arcuate in 12 cases (10.5%). In our cases, VA maintenance with fluid absorption was noted in 76 cases (66.7%) after the treatment. VA improvement with fluid absorption in 28 case (24.6%). Both VA maintenance and improvement (rate of efficiency) with fluid absorption were 91.2%. Fluid non-absorption or VA decline was regarded as unsuccessful in 10 cases (8.8%). The average thickness of 32 cases tumor pre- and post-treatment was (3.90 ± 1.15) mm and (2.41 ± 1.30) mm. Twenty seven cases were followed up for ≥ 1 year (mean 22.8 months) with rate of efficiency at 81.5%. The complications (9 eyes, 7.9%) contained minor macular hemorrhage in 2 eyes, macular pucker in 3 eyes, macular edema and cystoid macular edema in 2 eyes, retinal branch occlusion in 1 eye, and arcuate scotoma in 1 eye.
The treatment of TTT on CCH, whether the tumor located around-disc or in foveal area with exudative fluid could get successful in the majority of cases. TTT is one of the treatments worth doing owing to fewer complications, less expenses and easy-doing with definite and persistent effect.
研究经瞳孔温热疗法(TTT)治疗局限性脉络膜血管瘤(CCH)的效果。
这是一项回顾性病例系列研究。门诊114例(114眼)纳入研究,其中男性80例,女性34例。年龄16至71岁,平均44岁。所有病例均为单眼患病。采用间接检眼镜、眼底荧光血管造影(FFA)、超声(B超)进行检查。通过裂隙灯使用810nm二极管激光(Irises)进行治疗,用光斑或组合光斑(较大肿瘤)覆盖整个肿瘤。若肿瘤位于或部分位于黄斑区,应避免在黄斑中心凹和乳头黄斑束处进行激光光斑照射。在黄斑中心凹旁区域激光功率应较小(浅灰色)。在黄斑中心凹周边区域采用常规激光光斑(灰白色)。对于视盘旁肿瘤病例,激光光斑不应置于视盘边界外200μm宽度范围内。
治疗前后视力(VA)≥0.5者分别为17眼(14.9%)和27眼(23.7%)。治疗前,27例(23.7%)视网膜脱离除肿瘤表面外在下方扩展。肿瘤位于黄斑区67例(58.8%),视盘周围35例(30.7%),颞侧弓形区12例(10.5%)。在我们的病例中,治疗后76例(66.7%)视力随积液吸收而维持。28例(24.6%)视力随积液吸收而提高。视力随积液吸收维持和提高(有效率)共91.2%。10例(8.8%)积液未吸收或视力下降被视为治疗失败。32例肿瘤治疗前后平均厚度分别为(3.90±1.15)mm和(2.41±1.30)mm。27例随访≥1年(平均22.8个月),有效率为81.5%。并发症9眼(7.9%),包括2眼轻度黄斑出血,3眼黄斑皱襞,2眼黄斑水肿和黄斑囊样水肿,1眼视网膜分支阻塞,1眼弓形暗点。
TTT治疗CCH,无论肿瘤位于视盘周围还是黄斑区伴渗出液,大多数病例均可成功。TTT并发症少、费用低、操作简便、效果确切持久,是值得开展的治疗方法之一。