New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Dermatol Clin. 2012 Jul;30(3):369-76. doi: 10.1016/j.det.2012.04.002. Epub 2012 Jun 15.
Total cumulative sun exposure is associated with the development of squamous cell and basal cell cancers, whereas intense intermittent sun exposure is associated with the development of melanoma. Exposure to UV radiation is the only known modifiable cause of melanoma, but the role of sunscreen in melanoma prevention remains somewhat controversial. This article discusses how UV radiation contributes to the pathogenesis of melanoma, how sunscreen modulates the action of UV radiation on the skin, and the effect of sunscreen on the risk of developing melanoma. A review of available sunscreen agents and their sun-protective properties is also included.
总的累计日照暴露与鳞状细胞癌和基底细胞癌的发展有关，而强烈的间歇性日照暴露与黑色素瘤的发展有关。紫外线辐射暴露是黑色素瘤唯一已知的可改变的原因，但防晒霜在预防黑色素瘤中的作用仍存在一些争议。本文讨论了紫外线辐射如何导致黑色素瘤的发病机制，防晒霜如何调节紫外线辐射对皮肤的作用，以及防晒霜对黑色素瘤发病风险的影响。还包括对现有防晒剂及其防晒性能的综述。
