Saha K, Chattopadhya D, Dash K, Saha U, Tyagi P K, Gupta M M, Paraashari A, Sharma A K
Department of Immunology, Vallabhbhai Patel Chest Institute, University of Delhi, India.
Int J Lepr Other Mycobact Dis. 1990 Dec;58(4):660-5.
Three-hundred-eighty-four leprosy patients were clinically examined for sexually transmitted diseases (STD) in north and northeastern India, revealing a high incidence (5.2%) of STD among them. Eighteen males, one female, and one eunuch were found to have chancroid ulcer, gonococcal urethritis, lymphogranuloma inguinale, and primary chancre. Of these patients, only 100, selected randomly, could be screened serologically for STD due to Treponema pallidum, herpes simplex (type 1 and 2), Entamoeba histolytica, hepatitis-associated virus, cytomegalovirus, Chlamydia trachomatis and human immunodeficiency virus (HIV); 100 control sera were included for comparison. In addition, sera from another 133 normal subjects and another 176 lepromatous patients were also screened for HIV antibody. Thus, a total of 233 normal sera and 276 leprosy sera were tested for HIV antibody. Although our leprosy patients have shown significantly high incidences of clinical STD and also high seropositivity against T. pallidum, herpes-simplex viruses types 1 and 2, hepatitis-associated virus, and cytomegalovirus, the search for antibody against HIV was negative. Our clinical and serological data suggest promiscuity in our patient population. The absence of HIV antibody in this high-risk population, however, seems to be an enigma.
在印度北部和东北部，对384名麻风病患者进行了性传播疾病（STD）的临床检查，结果显示他们中性传播疾病的发病率很高（5.2%）。发现18名男性、1名女性和1名阉人患有软下疳溃疡、淋菌性尿道炎、腹股沟淋巴肉芽肿和一期梅毒。在这些患者中，由于梅毒螺旋体、单纯疱疹（1型和2型）、溶组织内阿米巴、肝炎相关病毒、巨细胞病毒、沙眼衣原体和人类免疫缺陷病毒（HIV），仅随机挑选了100名患者进行性传播疾病的血清学筛查；纳入100份对照血清进行比较。此外，还对另外133名正常受试者和176名瘤型麻风患者的血清进行了HIV抗体筛查。因此，总共对233份正常血清和276份麻风病血清进行了HIV抗体检测。虽然我们的麻风病患者临床性传播疾病的发病率显著较高，并且对梅毒螺旋体、1型和2型单纯疱疹病毒、肝炎相关病毒和巨细胞病毒的血清阳性率也很高，但对HIV抗体的检测呈阴性。我们的临床和血清学数据表明我们的患者群体存在滥交行为。然而，在这个高危人群中未检测到HIV抗体似乎是一个谜。
