Cdk1 通过两种不同的机制驱动减数分裂和有丝分裂。

Cdk1 drives meiosis and mitosis through two different mechanisms.

出版信息

Cell Cycle. 2012 Aug 1;11(15):2763-4. doi: 10.4161/cc.21254.

DOI:10.4161/cc.21254

PMID:22801537

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3419047/

Abstract

Comment on: Adhikari D, et al. Hum Mol Gene 2012; 21:2476-84.

摘要

Adhikari D，等。人类分子基因 2012；21：2476-84。

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Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes.

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Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3826-31. doi: 10.1073/pnas.1115201109. Epub 2012 Feb 21.

Cell biology. Enforcing the Greatwall in mitosis.

Science. 2010 Dec 17;330(6011):1638-9. doi: 10.1126/science.1199898.

Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12564-9. doi: 10.1073/pnas.0914191107. Epub 2010 Jun 10.

Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms.

Oncogene. 2009 Aug 20;28(33):2925-39. doi: 10.1038/onc.2009.170. Epub 2009 Jun 29.

Cdk1 is sufficient to drive the mammalian cell cycle.

Nature. 2007 Aug 16;448(7155):811-5. doi: 10.1038/nature06046.

Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts.

Mol Cell. 2006 Apr 7;22(1):83-91. doi: 10.1016/j.molcel.2006.02.022.

Stops and starts in mammalian oocytes: recent advances in understanding the regulation of meiotic arrest and oocyte maturation.

Reproduction. 2005 Dec;130(6):791-9. doi: 10.1530/rep.1.00793.

Greatwall kinase: a nuclear protein required for proper chromosome condensation and mitotic progression in Drosophila.

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Cdk2 knockout mice are viable.

Curr Biol. 2003 Oct 14;13(20):1775-85. doi: 10.1016/j.cub.2003.09.024.

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Cdk1 通过两种不同的机制驱动减数分裂和有丝分裂。

Cdk1 drives meiosis and mitosis through two different mechanisms.

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