[疑似囊型包虫病患者抗细粒棘球绦虫抗体的调查]
[Investigation of anti-Echinococcus granulosus antibodies in patients with suspected cystic echinococcosis].
作者信息
Cetinkaya Ulfet, Hamamcı Berna, Kaya Muhittin, Gücüyetmez Süheyla, Kuk Salih, Yazar Süleyman, Sahin Izzet
机构信息
Erciyes Üniversitesi Tıp Fakültesi, Parazitoloji Anabilim Dalı, Kayseri, Türkiye.
出版信息
Turkiye Parazitol Derg. 2012;36(2):57-60. doi: 10.5152/tpd.2012.15.
OBJECTIVE
Cystic echninococcosis (CE) is an important helmintho-zoonotic disease causing health-threatening and economic losses for developing countries. In this study, anti-Echinococcus granulosus antibodies were evaluated in 1556 CE suspected patients (701 males, 855 females) who applied to the serology laboratory of the Parasitology Department of Erciyes University between June 1999 and July 2010.
METHODS
Fifty-six (3.6%) patients were evaluated with the three different methods of Indirect Hemagglutination Test (IHA), Indirect Fluorescent Antibody Test (IFAT) and Western blot (WB). 378 (24.3%) were tested with both IHA and IFAT, 123 (7.9%) with both IHA and WB,and 999 (64.2%) were evaluated with one of these three methods.
RESULTS
In 353 (22.7%) patients, anti-E. granulosus antibodies detected by one of above three methods were considered as positive.
CONCLUSION
Since some patients were assessed either as negative or positive with one of above test, we believe that it should be safer to use at least two tests together for diagnosis of CE.
目的
囊性棘球蚴病（CE）是一种重要的蠕虫人畜共患病，给发展中国家带来健康威胁和经济损失。在本研究中，对1999年6月至2010年7月期间到埃尔西耶斯大学寄生虫学系血清学实验室就诊的1556例疑似CE患者（701例男性，855例女性）进行了抗细粒棘球绦虫抗体评估。
方法
采用间接血凝试验（IHA）、间接荧光抗体试验（IFAT）和蛋白质印迹法（WB）这三种不同方法对56例（3.6%）患者进行评估。378例（24.3%）患者同时进行了IHA和IFAT检测，123例（7.9%）同时进行了IHA和WB检测，999例（64.2%）患者采用这三种方法之一进行评估。
结果
353例（22.7%）患者中，通过上述三种方法之一检测到的抗细粒棘球绦虫抗体被视为阳性。
结论
由于部分患者在上述检测之一中被判定为阴性或阳性，我们认为，联合使用至少两种检测方法来诊断CE会更稳妥。
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