Suppr超能文献

对青蒿素类药物治疗系统性红斑狼疮作用机制的新认识。

New insights into mechanisms of therapeutic effects of antimalarial agents in SLE.

机构信息

Division of Rheumatology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Becker B-131, Los Angeles, CA 90048, USA.

出版信息

Nat Rev Rheumatol. 2012 Sep;8(9):522-33. doi: 10.1038/nrrheum.2012.106. Epub 2012 Jul 17.

Abstract

Antimalarial agents have routinely been used for the treatment of systemic lupus erythematosus (SLE) for over 50 years. These agents continue to enjoy success as the initial pharmacotherapy for SLE even in the era of targeted therapies. Antimalarial agents have numerous biological effects that are responsible for their immunomodulatory actions in SLE. Their inhibitory effect on Toll-like receptor-mediated activation of the innate immune response is perhaps the most important discovery regarding their putative mechanism of action, but some other, previously known properties, such as antithrombotic and antilipidaemic effects, are now explained by new research. In the 1980s and 1990s, these antihyperlipidaemic and antithrombotic effects were demonstrated in retrospective clinical studies, and over the past few years prospective studies have confirmed those findings. Knowledge about the risk-benefit profile of antimalarial agents during pregnancy and lactation has evolved, as has the concept of retinal toxicity. Antimalarial agents have unique disease-modifying properties in SLE and newer iterations of this class of anti-inflammatory agents will have a profound effect upon the treatment of autoimmune disease.

摘要

抗疟药物在过去 50 多年中一直被常规用于治疗系统性红斑狼疮(SLE)。即使在靶向治疗时代,这些药物仍然作为 SLE 的初始药物治疗而取得成功。抗疟药物具有多种生物学作用,这是它们在 SLE 中发挥免疫调节作用的原因。它们对 Toll 样受体介导的固有免疫反应激活的抑制作用可能是关于其作用机制的最重要发现,但其他一些以前已知的特性,如抗血栓形成和抗脂质作用,现在可以用新的研究来解释。在 20 世纪 80 年代和 90 年代,这些抗高血脂和抗血栓形成的作用在回顾性临床研究中得到了证实,在过去几年中,前瞻性研究也证实了这些发现。关于妊娠和哺乳期抗疟药物的风险-效益情况的认识已经发生了变化,视网膜毒性的概念也是如此。抗疟药物在 SLE 中具有独特的疾病修饰特性,这种新型抗炎药物将对自身免疫性疾病的治疗产生深远影响。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验