野生型p53会削弱对化疗的反应：化不利为有利以保护正常细胞。
Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells.
作者信息
Blagosklonny Mikhail V
机构信息
Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
出版信息
Oncotarget. 2012 Jun;3(6):601-7. doi: 10.18632/oncotarget.548.
Abstract
As published recently in Cancer Cell, p53 impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. I discuss that, while treating tumors lacking wt p53, this phenomenon can be exploited to protect normal cells from chemotherapy because all normal cells have wt p53. Also, several therapeutic paradigms can be reassessed, including the role of cellular senescence in cancer therapy.
摘要
正如最近发表在《癌细胞》杂志上的文章所述，p53会削弱乳腺癌对化疗的凋亡反应及临床疗效。我认为，在治疗缺乏野生型p53的肿瘤时，这一现象可被利用来保护正常细胞免受化疗影响，因为所有正常细胞都有野生型p53。此外，包括细胞衰老在癌症治疗中的作用在内的几种治疗模式都可重新评估。
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