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Intermittent supplementation with rapamycin as a dietary restriction mimetic.

作者信息

Longo Valter D, Fontana Luigi

出版信息

Aging (Albany NY). 2011 Nov;3(11):1039-40. doi: 10.18632/aging.100401.

DOI:10.18632/aging.100401
PMID:22147496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3249447/
Abstract
摘要

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本文引用的文献

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Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.雷帕霉素可延长近交系雌性小鼠的寿命并抑制自发性肿瘤发生。
Cell Cycle. 2011 Dec 15;10(24):4230-6. doi: 10.4161/cc.10.24.18486.
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Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.生长激素受体缺乏与人类衰老相关信号、癌症和糖尿病的大幅减少有关。
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Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.雷帕霉素而非白藜芦醇或辛伐他汀可延长遗传异质性小鼠的寿命。
J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. doi: 10.1093/gerona/glq178. Epub 2010 Oct 25.
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The potential benefits of rapamycin on renal function, tolerance, fibrosis, and malignancy following transplantation.雷帕霉素在移植后对肾功能、耐受性、纤维化和恶性肿瘤的潜在益处。
Kidney Int. 2010 Dec;78(11):1075-9. doi: 10.1038/ki.2010.324. Epub 2010 Sep 22.
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Extending healthy life span--from yeast to humans.延长健康寿命——从酵母到人类。
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Calorie restriction and cancer prevention: metabolic and molecular mechanisms.热量限制与癌症预防：代谢和分子机制。
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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.核糖体蛋白S6激酶1信号通路调节哺乳动物寿命。
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Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism.癌基因同源物Sch9通过超氧化物和Rev1/Polzeta依赖性机制促进年龄依赖性突变。
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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.在生命后期喂食雷帕霉素可延长基因异质小鼠的寿命。
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Immunoregulatory functions of mTOR inhibition.mTOR抑制的免疫调节功能。
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