Intermittent supplementation with rapamycin as a dietary restriction mimetic.
作者信息
Longo Valter D, Fontana Luigi
出版信息
Aging (Albany NY). 2011 Nov;3(11):1039-40. doi: 10.18632/aging.100401.
Abstract
摘要
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本文引用的文献
1
Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.雷帕霉素可延长近交系雌性小鼠的寿命并抑制自发性肿瘤发生。
Cell Cycle. 2011 Dec 15;10(24):4230-6. doi: 10.4161/cc.10.24.18486.
2
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.生长激素受体缺乏与人类衰老相关信号、癌症和糖尿病的大幅减少有关。
Sci Transl Med. 2011 Feb 16;3(70):70ra13. doi: 10.1126/scitranslmed.3001845.
3
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.雷帕霉素而非白藜芦醇或辛伐他汀可延长遗传异质性小鼠的寿命。
J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. doi: 10.1093/gerona/glq178. Epub 2010 Oct 25.
4
The potential benefits of rapamycin on renal function, tolerance, fibrosis, and malignancy following transplantation.雷帕霉素在移植后对肾功能、耐受性、纤维化和恶性肿瘤的潜在益处。
Kidney Int. 2010 Dec;78(11):1075-9. doi: 10.1038/ki.2010.324. Epub 2010 Sep 22.
5
Extending healthy life span--from yeast to humans.延长健康寿命——从酵母到人类。
Science. 2010 Apr 16;328(5976):321-6. doi: 10.1126/science.1172539.
6
Calorie restriction and cancer prevention: metabolic and molecular mechanisms.热量限制与癌症预防：代谢和分子机制。
Trends Pharmacol Sci. 2010 Feb;31(2):89-98. doi: 10.1016/j.tips.2009.11.004. Epub 2010 Jan 25.
7
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.核糖体蛋白S6激酶1信号通路调节哺乳动物寿命。
Science. 2009 Oct 2;326(5949):140-4. doi: 10.1126/science.1177221.
8
Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism.癌基因同源物Sch9通过超氧化物和Rev1/Polzeta依赖性机制促进年龄依赖性突变。
J Cell Biol. 2009 Aug 24;186(4):509-23. doi: 10.1083/jcb.200906011. Epub 2009 Aug 17.
9
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.在生命后期喂食雷帕霉素可延长基因异质小鼠的寿命。
Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221. Epub 2009 Jul 8.
10
Immunoregulatory functions of mTOR inhibition.mTOR抑制的免疫调节功能。
Nat Rev Immunol. 2009 May;9(5):324-37. doi: 10.1038/nri2546.
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