一名重症肌无力患者体内的生长激素自身抗体。

Autoantibody to growth hormone in a patient with myasthenia gravis.

作者信息

Okada S, Saito E, Oshima H, Kinoshita M

机构信息

Fourth Department of Medicine, School of Medicine, Toho University, Tokyo, Japan.

出版信息

J Endocrinol. 1990 Dec;127(3):533-8. doi: 10.1677/joe.0.1270533.

DOI:10.1677/joe.0.1270533

PMID:2280216

Abstract

An autoantibody to GH was detected in the serum from a patient with myasthenia gravis (MG) who had never been prescribed GH. Using an immunoprecipitation technique, this autoantibody was found to belong to the IgG class and had a kappa chain. The dissociation constant of the antibody was 56.8 nmol/l and the binding capacity was 37 nmol/l. Serum samples from another 130 patients, including 37 with MG, were examined, but the GH autoantibody could not be detected. To our knowledge, this is the first report demonstrating the presence of a GH autoantibody.

摘要

在一名从未使用过生长激素（GH）的重症肌无力（MG）患者的血清中检测到了一种抗GH自身抗体。采用免疫沉淀技术发现，这种自身抗体属于IgG类，具有κ链。该抗体的解离常数为56.8 nmol/l，结合能力为37 nmol/l。对另外130名患者的血清样本进行了检测，其中包括37名MG患者，但未检测到GH自身抗体。据我们所知，这是首次报道证明存在GH自身抗体。