Delbue Serena, Ferraresso Mariano, Ghio Luciana, Carloni Camilla, Carluccio Silvia, Belingheri Mirco, Edefonti Alberto, Ferrante Pasquale
Laboratory of Translational Research, Health Science Foundation "Ettore Sansavini", Corso Garibaldi 11, 48022 Lugo, Italy.
Clin Dev Immunol. 2013;2013:926391. doi: 10.1155/2013/926391. Epub 2013 Jan 29.
The polyomavirus (PyV), JC virus (JCV), is a small nonenveloped DNA virus that asymptomatically infects about 80% of healthy adults and establishes latency in the kidney tissue. In case of immunodeficient hosts, JCV can lytically infect the oligodendrocytes, causing a fatal demyelinating disease, known as progressive multifocal leukoencephalopathy (PML). Although the reactivation of another human PyV, BK virus (BKV), is relatively common and its association with the polyomavirus associated nephropathy (PyVAN) following renal transplantation is proven, JCV replication and its impact on graft function and survival are less well studied. Here we describe the biology of JCV and its pathological features and we review the literature regarding the JCV infection analyzed in the setting of transplantations.
多瘤病毒（PyV）中的JC病毒（JCV）是一种小型无包膜DNA病毒，约80%的健康成年人会被其无症状感染，并在肾脏组织中建立潜伏感染。在免疫缺陷宿主中，JCV可裂解性感染少突胶质细胞，引发一种致命的脱髓鞘疾病，即进行性多灶性白质脑病（PML）。尽管另一种人类多瘤病毒BK病毒（BKV）的再激活相对常见，且已证实其与肾移植后多瘤病毒相关性肾病（PyVAN）有关，但JCV的复制及其对移植肾功能和存活的影响研究较少。在此，我们描述JCV的生物学特性及其病理特征，并回顾在移植背景下分析JCV感染的相关文献。
