Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Cancer Res Treat. 2012 Jun;44(2):85-96. doi: 10.4143/crt.2012.44.2.85. Epub 2012 Jun 30.
Despite their rarity in incidence and prevalence, gastrointestinal stromal tumors (GISTs) have emerged as a distinct and noteworthy pathogenetic entity. The clinical management of GISTs has rapidly evolved due to the recent elucidation of their oncogenic signal transduction pathway and the introduction of molecular-targeted therapies. Successful management of GISTs requires a multidisciplinary approach firmly based on an accurate histopathologic diagnosis. In 2007, the Korean GIST study group published the first guideline for optimal diagnosis and treatment of GISTs in Korea. The second version of the guideline was published in 2010. Herein, we provide the results of relevant clinical studies for the purpose of further revision to the guideline. We expect this new guideline will enhance the accuracy of diagnosis, as performed by members of the Korean associate of physicians involved in GIST patient care, thus improving the efficacy of treatment.
尽管胃肠道间质瘤（GISTs）的发病率和患病率较低，但它们已成为一种独特且值得注意的发病实体。由于其致癌信号转导通路的新近阐明以及分子靶向治疗的引入，GIST 的临床管理已经迅速发展。成功管理 GIST 需要一种多学科方法，该方法牢固地基于准确的组织病理学诊断。2007 年，韩国 GIST 研究小组发表了韩国 GIST 最佳诊断和治疗的首项指南。该指南的第二版于 2010 年发布。在此，我们提供了相关临床研究的结果，目的是进一步修订该指南。我们希望本新指南将提高参与 GIST 患者治疗的韩国内科医生协会成员的诊断准确性，从而提高治疗效果。
