Vijayakumar M, Bhaskaram P, Hemalatha P
National Institute of Nutrition, Indian Council of Medical Research, Hyderabad.
J Trop Pediatr. 1990 Dec;36(6):294-8. doi: 10.1093/tropej/36.6.294.
Cell-mediated immune status (CMI) of sixty-five children suffering from various clinical forms of tuberculosis and thirty age- and sex-matched healthy children aged between 1 and 5 years was investigated to understand the role of malnutrition in tuberculosis. A significant association between severe malnutrition and severe forms of infection was observed. Data on CMI showed immunosuppressive effect of tuberculosis per se in all children. Well nourished children had similar CMI status irrespective of the severity of the disease while malnourished children with severe forms of disease showed lowest CMI response. These data suggest not only the synergistic interactions of malnutrition and tuberculosis, but the contributory role of malnutrition in causing more severe immuno suppression. The results point out the importance of better nutritional status of the child in preventing the severe forms of the disease.
对65名患有各种临床类型结核病的儿童以及30名年龄和性别匹配、年龄在1至5岁之间的健康儿童的细胞介导免疫状态（CMI）进行了调查，以了解营养不良在结核病中的作用。观察到严重营养不良与严重感染形式之间存在显著关联。CMI数据显示，结核病本身对所有儿童都有免疫抑制作用。营养良好的儿童，无论疾病严重程度如何，其CMI状态相似；而患有严重疾病形式的营养不良儿童的CMI反应最低。这些数据不仅表明了营养不良与结核病的协同相互作用，还表明了营养不良在导致更严重免疫抑制方面的作用。结果指出了改善儿童营养状况对预防严重疾病形式的重要性。
