Bhaskaram P, Sundaramma M N
National Institute of Nutrition, Hyderabad, India.
Eur J Clin Nutr. 1990 Mar;44(3):245-8.
The effect of associated malnutrition on the functional status of peripheral blood monocytes activated in vitro was tested in patients suffering from pulmonary tuberculosis, contacts and healthy controls. The capacity of the in vitro activated monocytes (MO) to generate hydrogen peroxide (H2O2), superoxide (O-2) and interleukin-1 (IL1) was tested. The results indicated that the patients and contacts were significantly malnourished compared to the controls. The MO functions, however, were comparable among the three groups indicating lack of in vivo activation of the MO in patients harbouring tubercular infection/disease. With the evidence available from the literature on the effects of malnutrition on cellular immune functions, it was speculated that the observed MO dysfunction could be due to lack of appropriate lymphokine elaboration due to associated malnutrition. The observed immunological defect might increase the risk of overt infection among the malnourished contacts.
在肺结核患者、接触者及健康对照中，测试了相关营养不良对体外激活的外周血单核细胞功能状态的影响。检测了体外激活的单核细胞（MO）产生过氧化氢（H2O2）、超氧化物（O-2）和白细胞介素-1（IL1）的能力。结果表明，与对照组相比，患者和接触者存在明显的营养不良。然而，三组之间的MO功能相当，这表明患有结核感染/疾病的患者体内的MO缺乏激活。根据文献中关于营养不良对细胞免疫功能影响的现有证据推测，观察到的MO功能障碍可能是由于相关营养不良导致缺乏适当的淋巴因子分泌。观察到的免疫缺陷可能会增加营养不良接触者发生明显感染的风险。
