Sugimura M, Shirogane D, Atoji Y, Suzuki Y, Ohshima K, Kon Y, Hashimoto Y
Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Nihon Juigaku Zasshi. 1990 Oct;52(5):1015-21. doi: 10.1292/jvms1939.52.1015.
S-100 protein-immunoreactive cells of the lymph node were examined in the duck and 9 mammalian species, such as guinea pigs, dogs, cats, horses, pigs, goats, cows, Japanese serows and crab-eating monkeys. S-100 protein was detected in follicular dendritic cells (FDC) and tangible-body macrophages (TBM), sinus and parenchymal macrophage (MP), sinus endothelial cells (SEC) and interdigitating reticulum-like cells (IRC) in the node of mammalian species, but not in the duck except nervous elements. S-100-positive FDC and TBM were detected in germinal centers of the nodes in all mammalian species, but immunoreactivity of the other 3 cell types varied according to animal species and individuals of the same species. S-100 alpha subunit was detected in FDC, with the exception of those of the duck and guinea pig. The subunit was also detected in SEC of the dog, cow and Japanese serow. In the guinea pig, a unique S-100 alpha-positive giant dendritic cell (GDC) was found in the subsinusal cortical area. In addition, S-100 immunoreactive lymphocytes were observed in the paracortex-equivalent area of pig nodes. Arterial endothelial cells of the pig and cow were immunoreactive to S-100 beta subunit.
对鸭以及豚鼠、狗、猫、马、猪、山羊、牛、日本鬣羚和食蟹猴等9种哺乳动物的淋巴结中S-100蛋白免疫反应性细胞进行了检查。在哺乳动物的淋巴结中，滤泡树突状细胞（FDC）、明细胞巨噬细胞（TBM）、窦和实质巨噬细胞（MP）、窦内皮细胞（SEC）和交错网状样细胞（IRC）中检测到S-100蛋白，但鸭的淋巴结中除神经成分外未检测到。在所有哺乳动物的淋巴结生发中心均检测到S-100阳性的FDC和TBM，但其他3种细胞类型的免疫反应性因动物种类和同一物种的个体而异。除鸭和豚鼠的FDC外，在其他动物的FDC中均检测到S-100α亚基。在狗、牛和日本鬣羚的SEC中也检测到该亚基。在豚鼠的窦下皮质区域发现了一种独特的S-100α阳性巨树突状细胞（GDC）。此外，在猪淋巴结的副皮质等效区域观察到S-100免疫反应性淋巴细胞。猪和牛的动脉内皮细胞对S-100β亚基有免疫反应。
