Nakajima T, Watanabe S, Sato Y, Shimosato Y, Motoi M, Lennert K
Gan. 1982 Jun;73(3):429-32.
S-100 protein was immunohistochemically demonstrated in the cells of cases of histiocytosis X such as eosinophilic granuloma, Hand-Schüller-Christian disease and Letterer-Siwe disease. Its presence was also shown in Langerhans cells of the epidermis and interdigitating reticulum cells in the lymph node, spleen and thymus. S-100 protein was not found in epithelioid cells in sarcoidosis, phagocytic macrophages, or dendritic reticulum cells in germinal centers. S-100 protein might be a new immunohistochemical marker for the Langerhans cells, interdigitating reticulum cells and histiocytosis X cells.
S-100蛋白在组织细胞增多症X的病例细胞中通过免疫组织化学方法得以证实，如嗜酸性肉芽肿、汉-许-克病和勒-雪病。其在表皮的朗格汉斯细胞以及淋巴结、脾脏和胸腺中的交错突网状细胞中也有表达。在结节病的上皮样细胞、吞噬性巨噬细胞或生发中心的树突状网状细胞中未发现S-100蛋白。S-100蛋白可能是朗格汉斯细胞、交错突网状细胞和组织细胞增多症X细胞的一种新的免疫组织化学标志物。
