Université Paris Descartes, Laboratoire Santé Publique et Environnement - EA 4064, Paris, France.
J Expo Sci Environ Epidemiol. 2013 Mar;23(2):145-50. doi: 10.1038/jes.2012.72. Epub 2012 Jul 18.
A cross sectional study using environmental and biological samples was undertaken to assess the association between arsenic (As) soil concentrations and urinary As levels of children living in an area where the soil is naturally As rich, during summer and winter. Twenty-nine children aged between 2 and 7 years from 21 dwellings in the summer study, and 23 of the 29 previous children from 17 dwellings in the winter study, were recruited. Housing characteristics, living conditions and individual characteristics were collected by questionnaire, and urine samples were collected for iAs+MMA+DMA measurement. Soil total As content and bioaccessibility were measured. Urinary As concentrations revealed that the children were not overexposed. Low bioaccessibility combined with moderately high levels in soil could explain this result. The concentration of arsenic in soil and soil-related factors appeared to contribute to the children's impregnation in summer but not in winter, which could be related to the children's behavior. This study highlights the need for additional studies of children to better understand their behavior, and obtain reference values in this particular population.
本研究采用环境和生物样本进行了横断面研究，以评估在土壤天然富含砷的地区，儿童夏季和冬季居住时土壤砷浓度与尿液砷水平之间的关联。从夏季研究的 21 个住宅中招募了 29 名年龄在 2 至 7 岁之间的儿童，以及冬季研究中 29 名儿童中的 23 名，从 17 个住宅中招募。通过问卷收集住房特征、生活条件和个体特征，并收集尿液样本以测量 iAs+MMA+DMA。测量了土壤总砷含量和生物可利用性。尿液砷浓度表明儿童没有过度暴露。低生物可利用性与土壤中中等高水平相结合可以解释这一结果。土壤中砷的浓度和土壤相关因素似乎导致了儿童在夏季的暴露，但在冬季没有，这可能与儿童的行为有关。本研究强调需要对儿童进行更多研究，以更好地了解他们的行为，并在这一特定人群中获得参考值。
