Université Paris Descartes, Laboratoire Santé Publique et Environnement, EA 4064, Paris, France.
Sci Total Environ. 2010 Nov 1;408(23):6011-6. doi: 10.1016/j.scitotenv.2010.08.039. Epub 2010 Sep 22.
A cross sectional study using environmental and biological samples was implemented to assess the association between arsenic (As) concentrations in the environment and urinary As levels of residents living in an area where the soil is naturally As rich. As was measured in drinking water, atmospheric particulate matter, and soil and a geographic information system was used to assign environmental concentrations closest to the participants' dwellings and the sum of inorganic As and metabolites in urine samples. The only potential source of As environmental contamination was from soil with a range of 13-131 mg As/kg of dry matter. As(V) was the only species present among As extracted from the analyzed soil samples. The chemical extraction showed a poor mobility of As soil. There was no difference between child and teenager, and adult urinary As concentrations, though men had higher urinary As concentrations than women (p<0.001). Given the important differences in lifestyle between 7-18 year olds, men, and women, these groups were analyzed separately. Whilst we were unable to find a stable model for the 7-18 year old group, for the adult men group we found that seafood consumption in the 3 days prior to the investigation (p=0.02), and beer (p=0.03) and wine consumption in the 4 days before the study, were associated with As urinary levels (μg/L). In adult women, creatinine was the only variable significantly associated with As urinary concentration (μg/L). The concentrations we measured in soils were variable and although high, only moderately so and no link between As concentrations in the soil and urinary As concentrations could be found for either men or women. Some individual factors explained half of the variability of adult men urinary As levels. The unexplained part of the variability should be searched notably in As mobility in soil and uncharacterized human behavior.
本研究采用环境和生物样本进行了横断面研究，以评估土壤天然富含砷地区居民环境砷浓度与尿砷水平之间的关联。检测了饮用水、大气颗粒物和土壤中的砷，使用地理信息系统将最接近参与者住所的环境浓度以及尿液样本中无机砷和代谢物的总和进行赋值。唯一可能的砷环境污染来源是土壤，其砷含量范围为 13-131mg/kg 干物质。在所分析的土壤样本中，砷提取出的唯一物种是 As(V)。化学提取表明土壤中砷的迁移性较差。儿童和青少年与成年的尿砷浓度之间没有差异，尽管男性的尿砷浓度高于女性（p<0.001）。鉴于 7-18 岁、男性和女性之间生活方式存在重要差异，对这些组分别进行了分析。虽然我们无法为 7-18 岁年龄组找到稳定的模型，但对于成年男性组，我们发现调查前 3 天的海鲜摄入量（p=0.02）以及研究前 4 天的啤酒（p=0.03）和葡萄酒摄入量与尿砷水平（μg/L）有关。对于成年女性，肌酐是唯一与尿砷浓度（μg/L）显著相关的变量。土壤中的浓度是可变的，虽然浓度较高，但仅为中度，无论是男性还是女性，均未发现土壤中砷浓度与尿砷浓度之间存在关联。一些个体因素解释了成年男性尿砷水平变异的一半。应特别注意寻找土壤中砷的迁移性和未被描述的人类行为来解释未解释的变异部分。
