Department of Oral and Maxillofacial Surgery, Facultad de Medicina y Odontología, Universidad de Oviedo, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain. jvicente@.uniovi.es
Head Neck. 2013 Jun;35(6):826-30. doi: 10.1002/hed.23038. Epub 2012 Jul 17.
Focal adhesion kinase (FAK) has been identified as a key mediator in tumor progression. The objective of this study was to determine the role of FAK as a predictor of neck node metastasis and poor prognosis in oral squamous cell carcinomas (OSCCs).
FAK expression in normal oral mucosa and in 69 OSCCs was examined by immunohistochemistry, and the percentage of stained cells was recorded. The correlation of these findings with clinicopathologic variables and survival was studied.
FAK expression in OSCCs was heterogeneous: 33.3% of cases showed weak expression; 23.2%, moderate expression, and 33.3% cases showed high expression. FAK expression significantly correlated with tumor size (p = .010), neck node metastasis (p = .01), and local tumor recurrence (p = .01). FAK expression was an independent prognostic factor in the survival analysis (p = .017).
Increased expression of FAK may play a role in invasiveness and metastasis of OSCCs, which contribute to poor prognosis and low survival.
黏着斑激酶（FAK）已被确定为肿瘤进展的关键介质。本研究旨在确定 FAK 作为口腔鳞状细胞癌（OSCC）颈部淋巴结转移和预后不良预测因子的作用。
采用免疫组织化学法检测正常口腔黏膜和 69 例 OSCC 中 FAK 的表达情况，并记录染色细胞的百分比。研究这些发现与临床病理变量和生存的相关性。
OSCC 中 FAK 的表达呈异质性：33.3%的病例表现为弱表达；23.2%为中度表达，33.3%的病例为高表达。FAK 的表达与肿瘤大小（p =.010）、颈部淋巴结转移（p =.01）和局部肿瘤复发（p =.01）显著相关。在生存分析中，FAK 表达是一个独立的预后因素（p =.017）。
FAK 的表达增加可能在 OSCC 的侵袭和转移中起作用，这导致了不良的预后和低生存率。
