Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
J Biophotonics. 2012 Nov;5(11-12):827-37. doi: 10.1002/jbio.201200077. Epub 2012 Jul 17.
We review the use of transcranial low-level laser (light) therapy (LLLT) as a possible treatment for traumatic-brain injury (TBI). The basic mechanisms of LLLT at the cellular and molecular level and its effects on the brain are outlined. Many interacting processes may contribute to the beneficial effects in TBI including neuroprotection, reduction of inflammation and stimulation of neurogenesis. Animal studies and clinical trials of transcranial-LLLT for ischemic stroke are summarized. Several laboratories have shown that LLLT is effective in increasing neurological performance and memory and learning in mouse models of TBI. There have been case report papers that show beneficial effects of transcranial-LLLT in a total of three patients with chronic TBI. Our laboratory has conducted three studies on LLLT and TBI in mice. One looked at pulsed-vs-continuous wave laser-irradiation and found 10 Hz to be superior. The second looked at four different laser-wavelengths (660, 730, 810, and 980 nm); only 660 and 810 nm were effective. The last looked at different treatment repetition regimens (1, 3 and 14-daily laser-treatments).
我们回顾了经颅低水平激光（光）疗法（LLLT）作为治疗创伤性脑损伤（TBI）的一种可能方法。概述了 LLLT 在细胞和分子水平上的基本机制及其对大脑的影响。许多相互作用的过程可能有助于 TBI 的有益效果，包括神经保护、减少炎症和刺激神经发生。总结了用于缺血性中风的经颅 LLLT 的动物研究和临床试验。几个实验室已经表明，LLLT 可有效提高 TBI 小鼠模型的神经功能、记忆力和学习能力。有几篇病例报告论文表明，经颅 LLLT 对三名慢性 TBI 患者有有益的影响。我们的实验室已经在小鼠中进行了三项关于 LLLT 和 TBI 的研究。一项研究比较了脉冲波与连续波激光照射，发现 10 Hz 更优。第二项研究观察了四种不同的激光波长（660、730、810 和 980nm）；只有 660nm 和 810nm 有效。最后一项研究了不同的治疗重复方案（1、3 和 14 天激光治疗）。
