Department of Food Science and Nutrition, Dankook University, 152, Jukjeon-ro, Suji-gu, Yongin-si, Gyeonggi 448-701, Korea.
Nutr Res Pract. 2012 Jun;6(3):195-200. doi: 10.4162/nrp.2012.6.3.195. Epub 2012 Jun 30.
The purpose of this study was to investigate the effects of α-lipoic acid on body weight and lipid profiles in Sprague-Dawley rats fed a high fat diet (HFD). After 4 weeks of feeding, rats on the HFD were divided into three groups by randomized block design; the first group received the high-fat-diet (n = 10), and the second group received the HFD administered with 0.25% α-lipoic acid (0.25LA), and the third group received the high-fat diet with 0.5% α-lipoic acid (0.5LA). The high fat diet with α-lipoic acid supplemented groups had significantly inhibited body weight gain, compared to that in the HFD group (P < 0.05). Organ weights of rats were also significantly reduced in liver, kidney, spleen, and visible fat tissues in rats supplemented with α-lipoic acid (P < 0.05). Significant differences in plasma lipid profiles, such as total lipids, total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein, were observed between the HFD and 0.5LA groups. The atherogenic index and the plasma high density lipoprotein-cholesterol/total cholesterol ratio improved significantly with α-lipoic acid supplementation in a dose-dependent manner (P < 0.05). Total hepatic cholesterol and total lipid concentration decreased significantly in high fat fed rats supplemented with α-lipoic acid in a dose-dependent manner (P < 0.05), whereas liver triglyceride content was not affected. In conclusion, α-lipoic acid supplementation had a positive effect on weight gain and plasma and liver lipid profiles in rats.
本研究旨在探讨α-硫辛酸对高脂饮食喂养的 Sprague-Dawley 大鼠体重和血脂谱的影响。经过 4 周的喂养，高脂饮食组大鼠采用随机区组设计分为三组；第一组给予高脂饮食（n = 10），第二组给予 0.25%α-硫辛酸（0.25LA）喂养的高脂饮食，第三组给予 0.5%α-硫辛酸（0.5LA）喂养的高脂饮食。与高脂饮食组相比，补充α-硫辛酸的高脂饮食组体重增长明显受到抑制（P < 0.05）。补充α-硫辛酸的大鼠的器官重量，如肝脏、肾脏、脾脏和可见脂肪组织的重量也明显减轻（P < 0.05）。在血浆脂质谱方面，如总脂质、总胆固醇、甘油三酯、低密度脂蛋白和高密度脂蛋白，高脂饮食组和 0.5LA 组之间存在显著差异。随着α-硫辛酸的补充，致动脉粥样硬化指数和血浆高密度脂蛋白胆固醇/总胆固醇比值显著改善，呈剂量依赖性（P < 0.05）。补充α-硫辛酸的高脂饮食大鼠的总肝胆固醇和总脂质浓度显著降低，呈剂量依赖性（P < 0.05），而肝甘油三酯含量不受影响。综上所述，α-硫辛酸补充对大鼠体重增加和血浆及肝脏脂质谱有积极影响。
