Agarwal Rashi, Goldenberg Matthew, Perry Robert, IsHak Waguih William
Brookdale University Hospital, Brooklyn, New York, USA.
Innov Clin Neurosci. 2012 May;9(5-6):10-21.
Across all medical specialties, quality of life has become an important measure of outcomes in both research and clinical settings. However, to date, there has not been a systematic review of the research relevant to quality of life in populations with adult attention deficit hyperactivity disorder. We approach quality of life in adult attention deficit hyperactivity disorder by answering the following questions: 1) What specific metrics are used to assess quality of life in adult attention deficit hyperactivity disorder? 2) What is the impact of adult attention deficit hyperactivity disorder on quality of life? 3) What effects do attention deficit hyperactivity disorder treatments have on quality of life? Searches of major electronic databases were conducted, and reference lists from the identified articles were searched for additional studies, with a focus on studies that utilized quality of life measures.
Thirty-six relevant studies are included in our review.
There are multiple unique measures currently used to measure quality of life in adult attention deficit hyperactivity disorder, ranging from general quality of life scales to those specifically designed for use in attention deficit hyperactivity disorder. Attention deficit hyperactivity disorder was found to significantly worsen the quality of life in adults. Treatment with atomoxetine and mixed amphetamine salts has shown beneficial effects on quality of life even in cases without symptomatology improvement.
Pharmacological treatment and early diagnosis have a positive impact on outcomes, longterm prognosis, and quality of life in adults with attention deficit hyperactivity disorder. Having multiple unique measures of quality of life have limited the direct comparison of different classes of attention deficit hyperactivity disorder medication treatments and future research should be aimed to address this.
在所有医学专科中，生活质量已成为研究和临床环境中衡量治疗结果的一项重要指标。然而，迄今为止，尚未对与成人注意力缺陷多动障碍（ADHD）患者生活质量相关的研究进行系统综述。我们通过回答以下问题来探讨成人ADHD患者的生活质量：1）用于评估成人ADHD患者生活质量的具体指标有哪些？2）成人ADHD对生活质量有何影响？3）ADHD治疗对生活质量有何作用？我们检索了主要电子数据库，并在已识别文章的参考文献列表中搜索其他研究，重点关注使用生活质量测量方法的研究。
我们的综述纳入了36项相关研究。
目前有多种独特的测量方法用于测量成人ADHD患者的生活质量，从一般生活质量量表到专门为ADHD设计的量表不等。研究发现，ADHD会显著恶化成人的生活质量。即使在症状没有改善的情况下，使用托莫西汀和混合苯丙胺盐进行治疗也已显示出对生活质量有有益影响。
药物治疗和早期诊断对成人ADHD患者的治疗结果、长期预后和生活质量有积极影响。生活质量有多种独特测量方法限制了不同类别ADHD药物治疗之间的直接比较，未来研究应致力于解决这一问题。
