Shahbazi Mahsa, Mihan Ronak, Sadighi Gita, Alikhani Rosa
Psychosis Research Center, University of Social Welfare & Rehabilitation Sciences, Tehran, Iran.
Psychiatr Q. 2025 Jul 16. doi: 10.1007/s11126-025-10189-9.
Psychiatric disorders negatively affect patients' quality of life (QoL) and increase caregiver burden. To compare QoL among patients with major depressive disorder (MDD), adult attention-deficit/hyperactivity disorder (aADHD), and personality disorders (PD), and to assess caregiver burden in these groups. This cross-sectional study included 240 patients (80 per diagnostic group) and their caregivers. Diagnoses were based on DSM-5-TR criteria; aADHD was confirmed with the Conners' Adult ADHD Rating Scale and DIVA 2.0. QoL was assessed with WHOQOL-BREF, and caregiver burden with the Zarit Burden Interview. Data were analyzed using SPSS v22. QoL was highest in aADHD (73.11 ± 7.50) and lowest in MDD (54.81 ± 13.60; p < 0.0001). Caregiver burden was highest among PD caregivers (59.53 ± 9.45) and lowest in aADHD caregivers (12.46 ± 6.18; p < 0.0001). Higher burden was linked to lower caregiver education (p = 0.037), unemployment (p = 0.022), and low income (p < 0.001). In MDD, caregiver burden was higher when patients had higher education (p = 0.045) or poor treatment adherence (p = 0.016). Male PD patients were associated with greater caregiver burden (p = 0.040). Frequent hospitalizations predicted lower QoL in MDD (p = 0.006). Patient QoL and caregiver burden were inversely correlated (r = -0.204, p = 0.001). QoL and caregiver burden differ by diagnosis. Socioeconomic factors strongly influence caregiver burden. Targeted, family-centered interventions are needed to improve outcomes.
精神障碍会对患者的生活质量（QoL）产生负面影响，并增加照料者的负担。比较重度抑郁症（MDD）、成人注意力缺陷多动障碍（aADHD）和人格障碍（PD）患者的生活质量，并评估这些群体中的照料者负担。这项横断面研究纳入了240名患者（每个诊断组80名）及其照料者。诊断基于《精神疾病诊断与统计手册》第5版修订版（DSM-5-TR）标准；aADHD通过康纳斯成人多动症评定量表和DIVA 2.0进行确诊。使用世界卫生组织生活质量简表（WHOQOL-BREF）评估生活质量，使用扎里特照料负担访谈量表评估照料者负担。数据使用SPSS v22进行分析。aADHD患者的生活质量最高（73.11±7.50），MDD患者的生活质量最低（54.81±13.60；p<0.0001）。PD患者照料者的负担最高（59.53±9.45），aADHD患者照料者的负担最低（12.46±6.18；p<0.0001）。更高的负担与照料者受教育程度较低（p=0.037）、失业（p=0.022）和低收入（p<0.oo1）有关。在MDD中，当患者受教育程度较高（p=0.045）或治疗依从性较差（p=0.016）时，照料者负担更高。男性PD患者与更高的照料者负担相关（p=0.040）。频繁住院预示着MDD患者的生活质量较低（p=0.006）。患者的生活质量与照料者负担呈负相关（r=-0.204，p=0.001）。生活质量和照料者负担因诊断而异。社会经济因素强烈影响照料者负担。需要有针对性的、以家庭为中心的干预措施来改善结果。
