Razina T G, Rybalkina O Yu, Lopatina K A, Amosova E N, Zueva E P, Khotimchenko M Yu, Khotimchenko Yu S
Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
Bull Exp Biol Med. 2011 Dec;152(2):231-5. doi: 10.1007/s10517-011-1496-4.
The effects of various alginate forms on the development of transplanted tumors in mice and efficiency of cytostatic therapy were studied. High-molecular-weight Ca and Na alginates, acid-soluble hydrolysate, and sodium alginate fraction inhibited the growth of Ehrlich adenocarcinoma. The use of acid-insoluble sodium alginate in chemotherapy protocol improved the treatment efficiency. All alginate forms inhibited metastasizing of Lewis pulmonary carcinoma; in combination with cyclophosphamide they potentiated its antimetastatic effect.
研究了各种藻酸盐形式对小鼠移植肿瘤生长及细胞抑制疗法效果的影响。高分子量的钙藻酸盐和钠藻酸盐、酸溶性水解产物以及海藻酸钠级分抑制了艾氏腺癌的生长。在化疗方案中使用酸不溶性海藻酸钠提高了治疗效果。所有藻酸盐形式均抑制了刘易斯肺癌的转移；与环磷酰胺联合使用时，它们增强了其抗转移作用。
