Pradhan G B, Shrestha R, Shrestha S, Neupane J, Bhattachan C L
Department of Surgery, Nepal Medical College and Teaching Hospital, Jorpati, Kathmandu, Nepal.
Nepal Med Coll J. 2011 Sep;13(3):169-71.
Thyroid carcinoma (TC) is a relatively rare tumour, but it represents the most frequent form of cancer of the endocrine glands. Epidemiologically ascertained risk factors are ionising radiation, the presence of thyroid adenoma and multinodular goiter (MNG). Multinodularity of goiter should no longer be considered an indicator of probable benign disease. A prospective analysis was performed on patients operated for multinodular Goiter at Nepal Medical College from January 2009 to November 2011, in order to establish the incidence of carcinoma. The results of this study, demonstrate that in 13.63 % of the patients operated for goiter, the presence of a carcinoma was noticed in the definitive histopathologic examination. Such incidence percentage of MNG is in accordance with the data reported in published reports. Thus, we conclude that the risk of malignancy in MNG has not to be underestimated, and that a dominant nodule in MNG should be valued as if it were a solitary nodule in an otherwise normal gland.
甲状腺癌（TC）是一种相对罕见的肿瘤，但它是内分泌腺最常见的癌症形式。经流行病学确定的风险因素包括电离辐射、甲状腺腺瘤和结节性甲状腺肿（MNG）的存在。甲状腺肿的多结节性不应再被视为可能为良性疾病的指标。为了确定癌症的发病率，对2009年1月至2011年11月在尼泊尔医学院接受多结节性甲状腺肿手术的患者进行了前瞻性分析。这项研究的结果表明，在接受甲状腺肿手术的患者中，有13.63%在最终的组织病理学检查中发现了癌症。MNG的这种发病率百分比与已发表报告中报道的数据一致。因此，我们得出结论，MNG中的恶性风险不应被低估，并且MNG中的优势结节应被视为正常腺体中的孤立结节一样进行评估。
