Cannon W C, Blanton E F, McDonald K E
Am Ind Hyg Assoc J. 1983 Dec;44(12):923-8. doi: 10.1080/15298668391405959.
We have designed a nose-only inhalation exposure chamber in which fresh aerosol is flowed past each exposure port and exhaled air is immediately exhausted. This allows all animals in the chamber to be exposed to the same aerosol concentration. In tests comparing initial lung burdens (ILB) of animals exposed in a standard chamber with those of animals exposed in the flow-past chamber, coefficients of variation in ILBs were significantly smaller for the latter.
我们设计了一种仅用于鼻腔吸入暴露的实验舱，在该实验舱中，新鲜气溶胶流经每个暴露端口，呼出的空气立即排出。这使得实验舱内的所有动物都暴露于相同的气溶胶浓度。在将标准实验舱中暴露的动物与流经式实验舱中暴露的动物的初始肺负荷（ILB）进行比较的测试中，后者ILB的变异系数显著更小。
