Smart Neil A, Steele Michael
School of Science and Technology, University of New England, Armidale, NSW, Australia.
Congest Heart Fail. 2012 Jul-Aug;18(4):205-11. doi: 10.1111/j.1751-7133.2011.00274.x. Epub 2011 Nov 27.
The authors compared the effects of continuous (CON) and intermittent (INT) exercise training programs on functional capacity, quality of life (QOL), and cardiac function in 23 congestive heart failure patients. Patients were randomized to CON exercise training (n=13; aged 66±7 years; peak oxygen consumption [VO(2)], 12.4±2.5 mL/kg/min; weight, 83±12 kg; left ventricular ejection fraction [LVEF], 29.5%±7.2%) or INT exercise training (n=10; aged 59±11 years; VO(2), 12.2±6.5 mL/kg/min; weight, 87±24 kg; LVEF 27%±7.9%). These groups completed 16 weeks of stationary cycling at 70% VO(2) thrice weekly for 30 minutes continuously or 60 minutes (60 seconds work:60 seconds rest) intermittently; both groups completed the same absolute volume of work. Three QOL questionnaire responses, VO(2), LVEF, and regional tissue Doppler were quantified. After exercise training, VO(2) increased by 13% in the CON group (P=.12) and significantly by 21% in the INT group (P=.03), although not significantly between the groups (P=.72). In the CON group, Minnesota Living With Heart Failure score improved at 16 weeks (P=.02), while in the INT group, Hare-Davis scores improved (P=.02). Cardiac volumes, resting and peak LVEF, contractile reserve, and tissue velocities were all unchanged from baseline. Intermittent exercise may improve functional capacity to a greater extent than continuous exercise. QOL changes were variable between groups.
作者比较了持续（CON）和间歇（INT）运动训练方案对23例充血性心力衰竭患者功能能力、生活质量（QOL）和心脏功能的影响。患者被随机分为CON运动训练组（n = 13；年龄66±7岁；峰值耗氧量[VO₂]，12.4±2.5 mL/kg/min；体重，83±12 kg；左心室射血分数[LVEF]，29.5%±7.2%）或INT运动训练组（n = 10；年龄59±11岁；VO₂，12.2±6.5 mL/kg/min；体重，87±24 kg；LVEF 27%±7.9%）。这些组每周三次以70%VO₂进行16周的固定自行车运动，CON组持续30分钟，INT组间歇60分钟（60秒工作：60秒休息）；两组完成的绝对工作量相同。对三份QOL问卷回答、VO₂、LVEF和局部组织多普勒进行了量化。运动训练后，CON组VO₂增加了13%（P = 0.12），INT组显著增加了21%（P = 0.03），尽管两组间差异不显著（P = 0.72）。在CON组，明尼苏达心力衰竭生活评分在16周时改善（P = 0.02），而在INT组，Hare-Davis评分改善（P = 0.02）。心脏容积、静息和峰值LVEF、收缩储备和组织速度均与基线无变化。间歇运动可能比持续运动在更大程度上改善功能能力。两组间QOL变化各不相同。
