Department of Physiology, College of Medicine, University of Lagos, Idi-Araba, Nigeria.
Auton Neurosci. 2012 Sep 25;170(1-2):20-9. doi: 10.1016/j.autneu.2012.06.006. Epub 2012 Jul 17.
We recorded arterial pressure (BP) and heart rate (HR) in type-1 diabetic rats vs. controls for >6 months. Diabetic rats (DIAB) were maintained on insulin from the day glucose >250 mg/dl ("Day 0"). Weight was similar between groups until ~3 weeks before Day 0 when the weight in DIAB transiently lagged the controls (CONT); this difference was maintained throughout the study, but both groups otherwise gained weight in parallel. Plasma glucose attained 371 ± 109 (SD) mg/dl by day 1 in DIAB. Mean BP was similar across groups, and declined through the initial 4-6 months in both the CONT (at -0.06 ± 0.04 mmHg/day) and in the DIAB (at -0.14 ± 0.21 mmHg/day; NS vs. CONT). HR in the CONT (Month 1: 341 ± 13 bpm) exceeded DIAB (325 ± 25 bpm) through ~6 months after Day 0, and also decreased progressively over this period in CONT (-0.19 ± 0.14 bpm/day) and DIAB (-0.29 ± 0.23 bpm/day; NS vs. CONT) before leveling. The BP power within 0.35-0.45 Hz changed during the 90 min before vs. after the transition from dark to light, and light to dark; there were no between group differences. The slope of the log-log linear portion of the BP power spectrum between 1.0/h and 1/min was similar across groups, and increased in both from month 1 to month 6. Regulatory mechanisms maintain similar profiles in BP and HR in diabetic vs. control animals through the initial half year of the disease.
我们记录了 1 型糖尿病大鼠与对照组的动脉血压（BP）和心率（HR）超过 6 个月。糖尿病大鼠（DIAB）从血糖 >250mg/dl（“第 0 天”）开始就一直注射胰岛素。两组体重在第 0 天之前约 3 周时相似，此时 DIAB 的体重暂时落后于对照组（CONT）；这种差异一直持续到整个研究过程中，但两组体重都在平行增加。DIAB 的血糖在第 1 天达到 371±109（SD）mg/dl。两组的平均 BP 相似，在 CONT（-0.06±0.04mmHg/天）和 DIAB（-0.14±0.21mmHg/天；与 CONT 相比无统计学意义）中，BP 在最初的 4-6 个月内都有所下降。CONT 中的 HR（第 1 个月：341±13bpm）在第 0 天后的约 6 个月内一直高于 DIAB（325±25bpm），并且在 CONT（-0.19±0.14bpm/天）和 DIAB（-0.29±0.23bpm/天；与 CONT 相比无统计学意义）中，HR 在这期间也逐渐下降，然后趋于平稳。0.35-0.45Hz 之间的 BP 功率在从黑暗过渡到光亮以及从光亮过渡到黑暗的 90 分钟前与后发生了变化，两组之间没有差异。BP 功率谱在 1.0/h 到 1/min 之间的对数线性部分的斜率在两组之间相似，并且从第 1 个月到第 6 个月都有所增加。在疾病的最初半年，调节机制使糖尿病动物与对照动物的 BP 和 HR 保持相似的模式。
